Clocks and Rhythms

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CSHL Press, 2007 - Medical - 674 pages
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Based on presentations by world–renowned investigators at the 72nd annual Cold Spring Harbor Symposium on Quantitative Biology, this volume reviews the latest advances in biological clocks and rhythms. Topics include genetic and cellular studies aimed at characterizing circadian mechanisms; systems approaches to understanding physiological, endocrine, and neural networks; and models used for studying mental and physical cycles. A variety of normal and abnormal chronobiological patterns are discussed, including sleep, aging, migration, hibernation, seasonality, depression, and arrhythmias.
 

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Contents

Keeping Up with the Master Clock
301
Physiological Importance of a Circadian Clock Outside the Suprachiasmatic Nucleus
307
Regulation of Circadian Gene Expression in Liver by Systemic Signals and Hepatocyte Oscillators
319
Integrating the Circadian Oscillator into the Life of the Cyanobacterial Cell
331
Insights into the Life of a Eukaryotic Cell
339
Multiple Loops and Oscillators
345
Diurnal and Circadian Expression Profiling Modelbased Pattern Matching and Promoter Analysis
353
Systems Biology of Mammalian Circadian Clocks
365

Genetic and Molecular Analysis of the Central and Peripheral Circadian Clockwork of Mice
85
The Multiple Facets of Per2
94
Master Regulator CLOCK Is an Enzyme
105
Role in Timecompensated Sun Compass Orientation
113
Structure and Function of Animal Cryptochromes
118
Structure Function Analysis of Mammalian Cryptochromes
133
Translational Control of Circadian Expression
141
Posttranscriptional Regulation of Mammalian Circadian Clock Output
145
Biological Clocks and the Coordination Theory of RNA Operons and Regulons
157
Role of Phosphorylation in the Mammalian Circadian Clock
167
Posttranslational Regulation of Neurospora Circadian Clock by CK1adependent Phosphorylation
177
Posttranslational Control of the Neurospora Circadian Clock
185
Posttranslational Photomodulation of Circadian Amplitude
193
Insights into the Circadian Systems of Single Cells
201
Principles and Problems Revolving Round Rhythmrelated Genetic Variants
215
Synchronization of the Drosophila Circadian Clockby Temperature Cycles
233
What Is There Left to Learn about the Drosophila Clock?
243
Genetics and Neurobiology of Circadian Clocks in Mammals
251
A Tale of Two Species
261
Novel Insights from Genetic and Molecular Characterization of the Human Clock
273
Circadian Entrainment of Neurospora crassa
279
Constant Darkness Is a Mammalian Biological Signal
287
Entrainment of the Human Circadian Clock
293
Nuclear Receptors Metabolism and the Circadian Clock
387
Bacterial Circadian Programs
395
Stochastic Phase Oscillators and Circadian Bioluminescence Recordings
405
Reversible Protein Phosphorylation Regulates Circadian Rhythms
413
Evolution of the Clock from Yeast to Man by PeriodDoubling Folds in the Cellular Oscillator
421
Intracellular Developmental Timers
431
Transcriptional Feedback Loop Regulation Function and Ontogeny in Drosophila
437
The Vertebrate Segmentation Clock
445
Ultradian Oscillators in Somite Segmentation and Other Biological Events
451
The Role of Circadian Regulation in Cancer
459
Crosstalks between Circadian Timing System and Cell Division Cycle Determine Cancer Biology and Therapeutics
465
The Clock Proteins Aging and Tumorigenesis
477
Sirtuins in Aging and Disease
483
Identification of Caenorhabditis elegans Genes Regulating Longevity Using Enhanced RNAisensitive Strains
489
Circadian Photoreception in Vertebrates
499
Multiple Photoreceptors Contribute to Nonimageforming Visual Functions Predominantly through Melanopsin containing Retinal Ganglion Cells
509
Exploring Spatiotemporal Organization of SCN Circuits
527
Living in an Unpredictable World
543
Suprachiasmatic Nucleus Clock Time in the Mammalian Circadian System
551
Wake Cycles in Drosophila
557
Neurohormonal and Neuromodulatory Control of Sleep in Drosophila
565
Molecular Analysis of Sleep
573

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