Clostridia: Molecular Biology in the Post-genomic Era
Holger Brüggemann, Gerhard Gottschalk
Horizon Scientific Press, Jan 1, 2009 - Science - 230 pages
The genus Clostridium represents a heterogeneous group of anaerobic spore-forming bacteria, comprising prominent toxin-producing species, such as C. difficile, C. botulinum, C. tetani, and C. perfringens, in addition to well-known non-pathogens like solventogenic C. acetobutylicum. In the last decade, several clostridial genomes have been deciphered and post-genomic studies are currently underway. The advent of newly developed, genetic manipulation tools have permitted functional-based and systems biology analyses of several clostridial strains. Research in this area is at a very exciting stage. In this book, internationally recognized Clostridium experts critically review the most important aspects of clostridial research, providing the first coherent picture of the organism's molecular and cellular biology in this post-genomic era. The first major focus of the book is the genetics and molecular biology of the major clostridial toxins including: botulinum and tetanus neurotoxins, C. difficile large exotoxins, C. perfringens enterotoxin, pore-forming and binary bacterial toxins. Other topics include molecular epidemiology of C. botulinum and C. difficile, metabolic networks in C. acetobutylicum, development of genetic knock-out systems for clostridia, surface structures, anti tumor potential of clostridia, and antibiotic resistance determinants in C. difficile.
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acetobutylicum activity Aktories amino acids analysis anthracis anthrax toxin antibiotic antibiotic resistance antibodies Bacillus anthracis Bacillus binary toxins bacterial Bacteriol binding Biol BoNT BoNT/A botulinum C2 toxin botulinum neurotoxin botulism butyricum C-terminal C2II cancer CDCs cell wall characterization Chem clade Clin clostridial Clostridium acetobutylicum Clostridium botulinum Clostridium botulinum type Clostridium difficile Clostridium perfringens Clostridium perfringens enterotoxin complex components cytosol cytotoxicity detection difficile strains disease domain enterotoxin enzymes ermB FEMS Microbiol formation fragment function genes encoding genetic genome Gram-positive Hielm identified Immun infant botulism Infect insertion intron Korkeala Leppla Lindström locus McClane membrane Molecular molecule mutants neurotoxin neurotoxin gene oligomerization pathogen perfringens type plasmid Popoff pore prepore produced proteins proteolytic receptor region residues resistance ribotype S-layer septicum sigma factors species spores strain of Clostridium structure studies subtypes target TcdA TcdB tetani therapy tion toxin genes toxinotypes transcription transposon tumour Tweten variant virulence