Commercial and Pre-commercial Cell Detection Technologies for Defence Against Bioterror: Technology, Market and Society

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Laura M. Lechuga
IOS Press, 2008 - Political Science - 167 pages
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As a response to the rapidly emerging threat of bioterrorism, the objectives of this volume of Commercial and Pre-Commercial Cell Detection Technologies for Defence against Bioterror are to exchange information on commercially available technologies and equipment for defense against bioterrorism; to further the development of new biosensor system prototypes into a commercially available apparatus and to explore human factors in BWA biosensors. The new commercial and pre-commercial technologies that are currently emerging in the world are presented and explained. Furthermore, there is a discussion about the interaction of modern detection systems with society and a trial for improvement of the relation between the scientific community and commercial entities. There are four major areas highlighted: the first is a presentation of the most advanced biosensors and biodetection system which can be found in the market or are quite close to commercialization. Systems as the BIOHAWKacirc;b"cent;, SASS 2000, RAPTOR, BionasAcirc;reg; 2500, OWLS, or a portable SPR are presented in this section. The second issue is a presentation of the advances in the research of biodetection devices as DNA and protein microchips, micro and nanophotonic sensors, CMOS microsensor chips, electrochemical arrays, physical platforms, electro optical detection, mass detection, etc. Then, there is a description of the latest developments in the employment of bioreceptor layers for the selective detection of BWA, as protein signatures, molecular imprinted polymers, membrane engineering (MIME), cell signatures, monoclonal antibodies, synthetic antibodies and lytic phages, among others. The last part is the discussion of the human factor: societal issues related to sensor development and employment for BWA detection.
 

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Contents

Societal Issues and Deployment of Integrated Biological Sensors
1
Portable Nanobiosensor Platforms for Ultrasensitive Multidetection of Biological Warfare Agents in Real Time
10
Development and Testing of the Portable Electrochemical Immunosensor System for Detection of Bioagents
21
Disposable Screen Printed Electrochemical Sensors and Evaluation of Their Application as Alarm Systems Against Terrorism
30
New Generation Biosensors Based on Direct Bioelectrocatalysis and MultiMicrochannel Technology
38
ElectroOptical Analysis as a Tool for Determination of Microbial Cells with the Help of Specific Bacteriophages
45
Fast Measurement of Cells Status by ElectroOptical Technique
54
Detection of Cells and Viruses with Mass Sensitive Devices Applications of Synthetic Antibodies
60
CellBased Analyzing System for Continuous Determination of Cell Physiology
80
Biosensor Detection of Microorganisms Based on Registration of Their Metabolic Activity and Immunoassay
99
StateoftheArt Biosensor Technology for Instant UltraSpecific and UltraSensitive Detection of Infectious Disease Agents at Global Scale
115
LaserBased Point Detector for OnLine Identification of Biological Warfare Materials
125
PreSymptomatic Prediction of Illness in Mice Inoculated with Cowpox
132
PQQDehydrogenases as a Favorable Components for Biosensor Design
141
Biosensor Detection of Organophosphorous Gases
150
Author Index
167

Cell Monitoring Systems with CMOS MicroSensorChips
77

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