Comparative Toxicogenomics

Front Cover
Elsevier, Jul 11, 2008 - Science - 352 pages
Functional genomics has come of age. No longer is it an adventure for the avant garde scientist, but it has become an increasingly standardized mainstream tool accessible to any modern biological laboratory. Toxicogenomics studies are now generating an avalanche of data that, with the aid of established informatics methodology, is being translated into biologically meaningful information.

This is enabling us to start harvesting the benefits from years of investment in terms of technology, time, and (of course) money. It is therefore timely to bring together leading toxicologists with a wide variety of scientific aims in this book to demonstrate how microarray technology can be successfully applied to different research areas. This book transects biology from bacteria to human, from ecologically relevant sentinel organisms to well-characterized model species, and represents the full toxicogenomics arena from exploratory "blue sky" science to the prospects for incorporation into regulatory frameworks.

* Reviews some of the first really fruitful studies made in this area
* Covers different organisms ranging from humans to model species and environmental sentinels
* Provides a broad view of the area, increasing its attractiveness to researchers working in a variety of specialties
 

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Contents

unlocking the potential of the human genome
1
CHProgress in ecotoxicogenomics for environmental monitoring mode of action and toxicant identification
21
CHFish toxicogenomics
75
CHCurrent research in soil invertebrate ecotoxicogenomics
133
CHDaphnia as an emerging model for toxicological genomics
165
CHWhole genome microarray analysis of the expression profile of Escherichia coli in response to exposure to paranitrophenol
221
using the systems biology approach to assess chemical pollutants in the environment
249
Index of Authors
283
IDXSubject Index
319
Color plate section
323
Copyright

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