Elsevier, Jul 11, 2008 - Science - 352 pages
Functional genomics has come of age. No longer is it an adventure for the avant garde scientist, but it has become an increasingly standardized mainstream tool accessible to any modern biological laboratory. Toxicogenomics studies are now generating an avalanche of data that, with the aid of established informatics methodology, is being translated into biologically meaningful information.
This is enabling us to start harvesting the benefits from years of investment in terms of technology, time, and (of course) money. It is therefore timely to bring together leading toxicologists with a wide variety of scientific aims in this book to demonstrate how microarray technology can be successfully applied to different research areas. This book transects biology from bacteria to human, from ecologically relevant sentinel organisms to well-characterized model species, and represents the full toxicogenomics arena from exploratory "blue sky" science to the prospects for incorporation into regulatory frameworks.
* Reviews some of the first really fruitful studies made in this area
* Covers different organisms ranging from humans to model species and environmental sentinels
* Provides a broad view of the area, increasing its attractiveness to researchers working in a variety of specialties
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analysis application approach Aquat array Biochem Bioinformatics Biol biological biomarkers cadmium Caenorhabditis elegans cDNA microarray Chem chemical exposure clones clustering Colbourne coli compared complex compounds concentrations contaminants cytochrome P450 Daphnia Daphnia Genomics Consortium Daphnia magna data sets database Denslow differentially expressed downregulation drug earthworm ecological ecosystem ecotoxicogenomics ecotoxicology effects effluents elegans encoding endocrine disruption endpoints Environ environmental enzymes European flounder expressed sequence tags expression patterns fathead minnow fish function gene expression profiles genetic genome sequence Health Perspect identify induced interactions invertebrate investigated laboratory levels Linnaeus liver metabolism metabolites metabolomics methods mg/l mixtures molecular monitoring mRNA normalisation oestrogen organisms pathways phenotypic Physiol physiological pollutants populations potential predict protein proteomics pulex rainbow trout receptor regulatory reproduction risk assessment species statins studies systems biology systems toxicology toxicity toxicogenomics Toxicol toxicology transcriptional transcriptomics untreated upregulated vitellogenin zebrafish