Comprehensive Chiroptical Spectroscopy: Applications in Stereochemical Analysis of Synthetic Compounds, Natural Products, and Biomolecules

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Nina Berova, Prasad L. Polavarapu, Koji Nakanishi, Robert W. Woody
John Wiley & Sons, Feb 17, 2012 - Science - 872 pages
This book provides an introduction to the important methods of chiroptical spectroscopy in general, and circular dichroism (CD) in particular, which are increasingly important in all areas of chemistry, biochemistry, and structural biology. The book can be used as a text for undergraduate and graduate students and as a reference for researchers in academia and industry. Experimental methods and instrumentation are described with topics ranging from the most widely used methods (electronic and vibrational CD) to frontier areas such as nonlinear spectroscopy and photoelectron CD, as well as the theory of chiroptical methods and techniques for simulating chiroptical properties. Applications of chiroptical spectroscopy to problems in organic stereochemistry, inorganic stereochemistry, and biochemistry and structural biology are also discussed, and each chapter is written by one or more leading authorities with extensive experience in the field.

 

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Contents

ORGANIC STEREOCHEMISTRY
37
ELECTRONIC CD OF BENZENE AND OTHER AROMATIC
73
PRINCIPLES
115
THEORETICAL DETERMINATION OF THE ABSOLUTE
167
NATURAL PRODUCTS BY MEANS OF SOLIDSTATE ELECTRONIC
217
DYNAMIC STEREOCHEMISTRY AND CHIROPTICAL
251
SWITCHING
289
ELECTRONIC CIRCULAR DICHROISM OF SUPRAMOLECULAR
317
ELECTRONIC CIRCULAR DICHROISM OF PEPTIDES
499
ELECTRONIC CIRCULAR DICHROISM OF PEPTIDOMIMETICS
545
CIRCULAR DICHROISM SPECTROSCOPY OF NUCLEIC ACIDS
575
CIRCULAR DICHROISM OF PROTEINNUCLEIC ACID
615
DRUG AND NATURAL PRODUCT BINDING TO NUCLEIC ACIDS
635
PROBING HSA AND AGP DRUGBINDING SITES BY ELECTRONIC
665
CONFORMATIONAL STUDIES OF BIOPOLYMERS PEPTIDES
707
STRUCTURE AND BEHAVIOR OF BIOMOLECULES FROM RAMAN
759

THE ONLINE STEREOCHEMICAL ANALYSIS OF CHIRAL
355
DETERMINATION OF THE STRUCTURES OF CHIRAL NATURAL
387
INORGANIC STEREOCHEMISTRY
449
ELECTRONIC CIRCULAR DICHROISM OF PROTEINS
475
OPTICAL ROTATION ELECTRONIC CIRCULAR DICHROISM
795
ELECTRONIC CIRCULAR DICHROISM IN DRUG DISCOVERY
819
INDEX
843
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About the author (2012)

Nina Berova is a Research Professor in the Department of Chemistry at Columbia University. She has been a coeditor of the journal Chirality (Wiley) since 1998.

Prasad L. Polavarapu is currently a Professor of Chemistry at Vanderbilt University.

Koji Nakanishi is one of the world's leading natural products chemists and was editor of the journal, The Chemical Record (Wiley). He retired from Columbia University in 2007, but continues to conduct research.

Robert W. Woody is an Emeritus Professor at Colorado State University.

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