Comprehensive Toxicology, Volume 14I. Glenn Sipes This volume in the Comprehensive Toxicology series demonstrates how the use of extremely powerful molecular and cell biology techniques has stimulated the growth of toxicology as a scientific discipline. The field of toxicology has evolved from its earlier days of in vivo and descriptive studies to focusing on mechanisms. Frequently, mechanisms require an examination at the cellular and molecular level. Molecular toxicology has opened the door to comprehending the basic mechanisms of how toxicants show their effects. The volume is a comprehensive, integrated profile of the molecular effects of toxicants and the molecular mechanisms involved in producing cellular and tissue injury. |
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Acad aflatoxin agonist altered analysis apoptosis ARNT assays assessment Biochem Biol biological biomarkers Cancer Res carcinogenesis carcinogens caspase cDNA cell cycle cellular Chem chemical chromatin cloned coactivator complex compounds cyclin cytochrome database differentiation dioxin DNA binding DNA methylation domain dose drug effects environmental enzymes estrogen exposure Figure function gene expression genetic genome growth factor hepatocytes histone hormone human hypoxia identified induced inhibition inhibitor interaction levels ligand liver mammalian MAPK mechanism mediated metabolism mice microarray modulate molecular molecules motif mouse mRNA mutations nuclear receptor oxidative pathways peroxisome proliferator-activated receptor peroxisome proliferators Pharmacol phosphorylation polymorphisms PPAR predict Proc promoter prostate cancer protein kinase proteomics region regulation regulatory response elements risk role sample SAPK sequence signal transduction specific steroid structure studies subunit target tion tissue toxicity Toxicol toxicology transcription factors transcriptional activity transgenic tumor vitro vivo xenobiotic yeast