Comprehensive Virology: 7 Reproduction: Bacterial DNA Viruses
H. Fraenkel-Conrat, Robert R. Wagner
Springer US, 1977 - Medical - 300 pages
The time seems ripe for a critical compendium of that segment of the biological universe we call viruses. Virology, as a science, having passed only recently through its descriptive phase of naming and num bering, has probably reached that stage at which relatively few new~ truly new~viruses will be discovered. Triggered by the intellectual probes and techniques of molecular biology, genetics, biochemical cytology, and high-resolution microscopy and spectroscopy, the field has experienced a genuine information explosion. Few serious attempts have been made to chronicle these events. This comprehensive series, which will comprise some 6000 pages in a total of about 22 volumes, represents a commitment by a large group of active investigators to analyze, digest, and expostulate on the great mass of data relating to viruses, much of which is now amorphous and disjointed, and scattered throughout a wide literature. In this way, we hope to place the entire field in perspective, and to develop an invalu able reference and sourcebook for researchers and students at all levels. This series is designed as a continuum that can be entered anywhere, but which also provides a logical progression of developing facts and integrated concepts.
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Formation of the Parental RF
Expression of the Viral Genome
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Acad activity bacterial bacteriophage 0X174 bacteriophage M13 bacteriophage T4 baseplate binding Biochem Biol capsid chloramphenicol chromosome circular cleavage coat protein coliphage complementary strand contain CsCl Denhardt dimers DNA ligase DNA molecules DNA replication DNA synthesis dnaG duplex Escherichia coli Ff DNA filamentous fragments function gene 5 protein gene H gene product genome Hayashi heteroduplex Hofschneider host cell host DNA infected cells inhibition initiation involved isolated Kornberg labeled ligase located lysis mechanism membrane molecular weight mRNA mutants Natl nuclease nucleotides parental RF particles phage DNA precursor Proc progeny pyrimidine recombination replicating intermediates replicative form restriction endonuclease restriction enzyme RF molecules RF replication rifampicin RNA polymerase role Schekman sedimentation sequence single-stranded DNA synthesis Sinsheimer specific strand synthesis structure superhelical T-even phages T4 DNA tail tein teriophage Tessman tion transcription viral DNA viral strand virion Virol Virology virus viruses vitro vivo Wickner Zinder