Computer Aids to Clinical Decisions, Volume 2
Ben T. Williams
CRC Press, 1982 - Science - 216 pages
The specificity of certain chemicals to induce a wide variety of differing toxicities, including hepatotoxicity, neurotoxicity, pulmonary toxicity, nephrotoxicity, ototoxicity, and cancer in particular organs is a fascinating problem currently under active investigation in many laboratories.
This two-volume text provides a valuable reference for established investigators and postgraduate student in toxicology. Essential information on the general principles of target organ toxicity is provided in the first volume. It includes the importance of pharmacokinetics, metabolic activation and key defence mechanisms, excretion, species variation, and tissue specific biochemistry. Volume II illustrates these general principles by dealing with specific examples of toxicity to different target organs, such as lung, liver, kidney, nervous system, ear, eye, and the male and female reproductive systems.
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The General Applicability of Predictive Value Analysis
An Example of Predictive Value Analysis
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algorithm analysis Annu areas artificial intelligence artificial intelligence approaches associated biopsy calculated CASNET categorical and probabilistic causal complexity conditional probabilities Conf confirmed consultation systems context cost benefit ratio costs and benefits data bases decision tree derived descriptive knowledge diagnosis disease negative disease positive display domain Equation example expected value expert consultation False Negatives false positives Figure function goal graphic heuristic hypotheses important inference INTERNIST involved knowledge base knowledge representation knowledge-based systems likelihood medicine MYCIN negative predictive value node noted OPERATE STOP OPERATE operating point parameters path pathophysiologic patient description patient specific model pattern performance physician positive predictive value posterior probabilities prevalence probabilistic approaches probabilistic reasoning problem solving Proc procedures prostatic carcinoma rectal rectal examination referent value relationships represented ROC curve rules semantic networks Sens[A sensitivity and specificity solution Stage strategies structure subgoals tactical techniques test result