Computing for Comparative Microbial Genomics: Bioinformatics for Microbiologists

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Springer Science & Business Media, Dec 16, 2008 - Science - 270 pages
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Overview and Goals This book describes how to visualize and compare bacterial genomes. Sequencing technologies are becoming so inexpensive that soon going for a cup of coffee will be more expensive than sequencing a bacterial genome. Thus, there is a very real and pressing need for high-throughput computational methods to compare hundreds and thousands of bacterial genomes. It is a long road from molecular biology to systems biology, and in a sense this text can be thought of as a path bridging these ? elds. The goal of this book is to p- vide a coherent set of tools and a methodological framework for starting with raw DNA sequences and producing fully annotated genome sequences, and then using these to build up and test models about groups of interacting organisms within an environment or ecological niche. Organization and Features The text is divided into four main parts: Introduction, Comparative Genomics, Transcriptomics and Proteomics, and ? nally Microbial Communities. The ? rst ? ve chapters are introductions of various sorts. Each of these chapters represents an introduction to a speci? c scienti? c ? eld, to bring all readers up to the same basic level before proceeding on to the methods of comparing genomes. First, a brief overview of molecular biology and of the concept of sequences as biological inf- mation are given.
 

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Contents

Cells Obey the Laws
3
An Introduction
19
A New Era in Microbiology
37
An Overview of Genome Databases
53
a Brief Introduction
69
the First Examples
95
Length Base Composition
111
Word Frequencies and Repeats
137
9
153
12
213
Abbreviations
257
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