Computing for Comparative Microbial Genomics: Bioinformatics for Microbiologists
Springer Science & Business Media, Dec 16, 2008 - Science - 270 pages
Overview and Goals This book describes how to visualize and compare bacterial genomes. Sequencing technologies are becoming so inexpensive that soon going for a cup of coffee will be more expensive than sequencing a bacterial genome. Thus, there is a very real and pressing need for high-throughput computational methods to compare hundreds and thousands of bacterial genomes. It is a long road from molecular biology to systems biology, and in a sense this text can be thought of as a path bridging these ? elds. The goal of this book is to p- vide a coherent set of tools and a methodological framework for starting with raw DNA sequences and producing fully annotated genome sequences, and then using these to build up and test models about groups of interacting organisms within an environment or ecological niche. Organization and Features The text is divided into four main parts: Introduction, Comparative Genomics, Transcriptomics and Proteomics, and ? nally Microbial Communities. The ? rst ? ve chapters are introductions of various sorts. Each of these chapters represents an introduction to a speci? c scienti? c ? eld, to bring all readers up to the same basic level before proceeding on to the methods of comparing genomes. First, a brief overview of molecular biology and of the concept of sequences as biological inf- mation are given.
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16S rRNA accession number Actinobacteria alignment amino acids analysis annotation archaea AT-rich Atlases Bacillus bacterial genomes bacterium Base Atlas base composition binding bioinformatics biological BLAST Atlas Burkholderia cell Chapter chromosome codon codon usage color conserved contains core genome database devavg DNA sequence encoded enzyme Escherichia coli eukaryotic evolution example Firmicutes fix avg frequently function GC skew GenBank genetic Genome Atlas Genome islands genome sequence global direct repeats helix identify inverted repeats lane language leading strand metadata metagenomic molecules mRNA multiple NCBI nucleotide number of genes operon organisms palindromic pan-genome particular pathogen phyla plasmid plot PMID predicted present produced protein sequences Proteobacteria proteome pseudomallei purine reference genome regions represented ribosome rRNA genes rRNA operon secretion sequenced genomes shown in Fig sigma factors similar Stacking Energy strain Structure Atlas Swiss-Prot tmRNA transcription translation tRNA Ussery visualization