Concepts in Clinical Pharmacokinetics

Front Cover
ASHP, 2010 - Medical - 248 pages
Back Cover Copy:
The past four editions of Concepts in Clinical Pharmacokinetics have helped simplify a complex subject for thousands of pharmacy students and practitioners. The new, fifth edition of this popular teaching and self-instructional text makes it easier than ever to acquire a strong foundation in the basic principles of pharmacokinetics. The fundamental concepts along with mathematical equations are broken down to their simplest forms and a step-by-step approach is adopted to explain the “how to” of this discipline.

Completely reviewed and updated, the new edition includes all of the features that have made previous editions so effective and popular, plus many enhancements:
  • 15 lessons ideal for a 15-week semester course and/or self-study, each designed to build comprehension and mastery step-by-step
  • Self-assessment questions and practice calculations
  • Additional case studies, plus expansion of existing cases to include sections on monitoring parameters and appropriate “order writing.”
  • More clinical correlates, plus an expanded “cross-correlates” section for easy cross-referencing
  • An extensive new section of assessments of renal function
  • An expanded appendix summarizing the basic pharmacokinetic functions, and listing all equations needed to dose selected drugs
  • More in-depth answers and detailed feedback for incorrect responses
  • New graphics focus on relevant components of equations under discussion
The goal of this book remains the same - to provide the student or practitioner with the concepts and clinical applications needed for a better understanding of this complicated yet useful subject.
 

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Contents

Lessons and Practice Sets Lesson 1 Introduction to Pharmacokinetics and Pharmacodynamics
1
Basic Pharmacokinetics
19
HalfLife Elimination Rate and AUC
29
Practice Set 1
43
Intravenous Bolus Administration Multiple Drug Administration and SteadyState Average Concentrations
45
Relationships of Pharmacokinetic Parameters and Intravenous Intermittent and Continuous Infusions
59
TwoCompartment Models
73
Practice Set 2
83
Nonlinear Processes
131
Pharmacokinetic Variation and ModelIndependent
141
Practice Set 3
155
Vancomycin
179
Theophylline
195
Phenytoin and Digoxin
203
Appendix A Basic and DrugSpecific Pharmacokinetic Equations
217
Appendix B Supplemental Problems
225

Absorption
87
Drug Distribution and Protein Binding
103
Drug Elimination Processes
113
Glossary
231
Copyright

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About the author (2010)

Joseph T. DiPiro, Pharm.D. Dr. Joseph T. DiPiro is Executive Dean of the South Carolina College of Pharmacy, which is an intergrated program of the Colleges of Pharmacy at the University of South Carolina and the Medical University of South Carolina. Before coming to South Carolina, Dr. DiPiro was the Panoz Professor of Pharmacy at the University of Georgia College of Pharmacy and Clinical Professor of Surgery at the Medical College of Georgia. While there, he was also Assistant Dean for the College of Pharmacy and the School of Medicine at the Medical College of Georgia, and Head, Department of Clinical and Administrative Pharmacy. He received his BS in pharmacy from the University of Connecticut and Doctor of Pharmacy from the University of Kentucky. He served a residency at the University of Kentucky Medical Center and a fellowship in Clinical Immunology at Johns Hopkins University. He is the Editor of The American Journal of Pharmaceutical Education. Dr. DiPiro has published over 120 refereed papers in academic and professional journals, mainly related to antibiotics, drug use in surgery, various issues in pharmacy practice, and pharmacy education. His papers have appeared in Antimicrobial Agents and Chemotherapy, Pharmacotherapy, Critical Care Medicine, JAMA, Annals of Surgery, Archives of Surgery, American Journal of Surgery, Journal of Pharmacology and Experimental Therapeutics, and Surgical Infections. He is the senior editor for Pharmacotherapy: A Pathophysiologic Approach, now in its 6th edition. He is also the author of Concepts in Clinical Pharmacokinetics and Editor of the Encyclopedia of Clinical Pharmacy. He serves on the editorial boards of Pharmacotherapy and American Surgeon. He was a President of the American College of Clinical Pharmacy. He is a Fellow of the College and has served on the Research Institute Board of Trustees. He has been a member of the Surgical Infection Society Therapeutic Agents Committee and the American Society of Health-System Pharmacists, having served on the Commission on Therapeutics and the Task Force on Science. In 2002, the American Association of Colleges of Pharmacy selected Dr. DiPiro for the Robert K. Chalmers Distinguished Educator Award. He has also received the Russell R. Miller Literature Award and the Education Award from the American College of Clinical Pharmacy, the Award for Sustained Contributions to the Literature from the American Society of Health-System Pharmacists.

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