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Methods of Studying the Metabolism of Drugs
B Visible Absorption Spectrophotometry
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absorption acetylation Acta Amst activity alcohol Amer amines analogs analysis angiotensinase aromatic assay Axelrod barbiturates benzene bilirubin Biochem biol biological material biophys blood bradykinin Brodie carbon carboxypeptidase catalyzed cells Chem chemical chlorpromazine clin column compounds concentration conjugation cytochrome P-450 derivatives determination drug metabolism effect electron enzymatic enzyme Erdos esterase esters ethanol excretion extraction fluorescence formation fraction gas chromatography glucuronide glutathione hepatic heptane human hydrocarbons hydrolysis hydroxylase hydroxylation imipramine inactivation increased induced inhibition inhibitors isolated isotope kidney kininase Kuntzman labeled mercapturic acid metabolites method methyl microsomal enzyme microsomes molecular molecule Nature Lond organic oxidation oxygen peptide pharm Pharmacol pharmacological phase phenobarbital phenol plasma polar Proc procedure protein purified rabbit radioactive rat liver microsomes reaction reductase reduction sample sensitive serum soluble solution solvent specific spectra steroids studies substrate sulphate sulphotransferase synthesis technique Ther tion tissues transferase Udenfriend urine vitro vivo