Concise Clinical Pharmacology

Front Cover
Pharmaceutical Press, 2007 - Medical - 302 pages
This is a concise study guide and thorough introduction to clinical pharmacology from which students can gain a rapid understanding of individual topics within the discipline, and from which they can review and revise certain topics before exams. This is achieved through self-contained two-page "spreads" for each topic, with concise text on the left and a diagram on the right to elaborate and reinforce the text. To further underpin the text, additional two page spreads have been included where appropriate, with case histories on the left and Q&As on the right. The text has a strong clinical focus and, in the main, sections relate to particular body systems or the therapy of a disease-class (eg, cancer). Pharmacological principles and mechanisms are covered, but the main focus is on the therapeutic use of the drugs. Sections cover basic principles of pharmacology, specialised pharmacology (inc. in pregnancy, paediatrics, geriatrics), and the vitamins. The text has been written primarily for pharmacy students, but will also be of interest to clinical medical students. The strong clinical focus should also appeal to practitioners.
 

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Contents

Sources of modern drugs
4
Signal transduction and the receptor families
10
Clinical and human
16
Contents vii
21
Drug distribution
22
Renal drug excretion
28
The autonomic nervous system l Introduction
34
Receptors and drugs
40
Treatment
132
Treatment
134
Treatment Ill
136
Treatment IV
138
Headachel Nonmigraine headache
140
Migraine
142
Facial pain
144
Meningitis and encephalitis
146

Coagulation cascade
46
Anticoagulants l Heparin
52
Warfarin
54
Antiplatelet drugs
56
Thrombolytic and antifibrinolytic drugs
58
Myocardial infarction
60
Unstable anging
62
Transient ischaemic attack
64
Theories of brain mechanisms underlying seizures
65
Causes of dysrhythmias
66
Vaughan Williams classification of anti dysrhythmic drugs
68
Other antidysrhythmic drugs
70
Guidelines for treatment
72
Antihypertensive drugs
74
Congestive heart failure
76
Infective endocarditis
78
Lipid metabolism
80
Lipidlowering drugs
82
Mechanisms
84
Therapeutic use of aspirin
86
Other nonsteroidal antiinflammatory drugs NSAIDs
88
Paracetamol
90
Cortisol
92
Therapeutic use
94
Unwanted effects
96
Overview
98
Specific drugs
100
Introduction
102
SLE
104
Raynauds phenomenon and scleroderma
106
Gout
108
The perception of pain the gate theory
110
Palliative care
112
Opioids l Introduction
114
Clinical use
116
Introduction
118
Treatment
120
Treatment
122
Treatment Ill
124
Introduction
126
Occurrence and implications of epilepsy
128
the basis of drug action
130
General anaesthetics l Premedication
148
Induction of anaesthesia
150
Maintenance of anaesthesia
152
Muscle relaxants
154
Treatment of depression with drugs
156
Treatment of anxiety anxiolytic drugs
158
Treatment of insomnia
160
8 Antipsychotic drugs
162
Alzheimers disease
164
Drug addiction
166
Local anaesthetics
168
Peripheral neuropathies
170
Myasthenia gravis and LambertEaston myasthenic syndrome
172
Endocrine control systems
174
Treatment of growth disorders
176
Treatment of thyroid disorders
178
Treatment of adrenal disorders
180
9 The sex hormones
182
Oral contraceptives
184
Hormone replacement therapy
186
Drug treatment of breast cancer
188
Ovarian and prostate cancer
190
Type 1 diabetes mellitus DDM
192
Type 2 diabetes mellitus NIDDM
194
Osteoporosis
196
Gastrooesophageal reflux disease GERD
198
OO Gastric and duodenal ulceration and H pylori
200
Pancreatitis
202
Coeliac disease and carcinoids
204
O3 Diarrhoea and malabsorption
206
large bowel disorders l Ulcerative colitis
208
Crohns disease
210
Constipation
212
Worm infections
218
Introduction
224
Principles of treatment
230
Cystic fibrosis
236
Clinical uses of diuretics
242
Urinary tract infections
248
Sexually transmitted infections
254
Sources
282
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