Conformational Proteomics of Macromolecular Architecture: Approaching the Structure of Large Molecular Assemblies and Their Mechanisms of Action

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World Scientific, 2004 - Science - 420 pages
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Biological processes involving large macromolecular assemblies are thought to be a dynamic consequence of cooperativity and metastability. The folding of a peptide chain creates local environments from which “activity” can emerge. In the same way, the assembly of large molecular complexes creates dynamic features that would only be feasible in a large construct. The biological implications of such adaptation are explored as it applies to the static quasisymmetry situations, as well as to the dynamics of structural transitions. The current wealth of solved high-resolution complex structures makes this an appropriate time to summarize the state of the art in structural dynamics of living architectures. With contributions by leading scientists in the fields of virology, bacterial flagellum, cytoskeleton, ribosome and giant enzymes, this important book presents cutting-edge knowledge in the various fields of structural proteomics of very large molecular assemblies, with the focus on their mechanisms of action.
 

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Contents

Early Theories of Virus Structure
3
QuasiEquivalence and Adaptability in Living
41
The Role of Disordered Segments in Viral
53
Prefusion Dynamics in an Enveloped
78
Strategy to Obtain High Resolution Structure
111
On the Possibility of Determining Structures
133
Functional Details on Membrane Proteins Observed
148
Chapters Clathrin and Companions
161
The Dynamics of the Ribosome as Inferred
291
How do Translation Factors Catalyze Protein
307
Dynamic Aspects of the Bacterial Flagellum
333
Myosin Polymorphism and Muscle Contraction
345
Is Crystallization a Bottleneck of Modern
361
Sensor Surface Interactions in the Study
379
PPiDB A ProteinProtein Interactions Database
391
A Repository
403

Multistep
171
Metamorphosis of an Enzyme
198
Dynamics Flexibility
245

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