Congenital Disorders of Erythropoiesis
The Novartis Foundation Series is a popular collection of the proceedings from Novartis Foundation Symposia, in which groups of leading scientists from a range of topics across biology, chemistry and medicine assembled to present papers and discuss results. The Novartis Foundation, originally known as the Ciba Foundation, is well known to scientists and clinicians around the world.
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0t-chain abnormalities adult androgens anomalies aplasia aplastic anaemia B-chain bone marrow CDA type cDNA cell cycle cell population cellular chick chromatid chromo chromosome Clegg clinical colonies conﬁrmed congenital dyserythropoietic anaemia cultures cytoplasm defect deferoxamine deﬁnitive differentiation disorders embryo erythro erythroblasts erythrocytes erythroid erythroid cells erythropoiesis evidence Fanconi anaemia fetal haemoglobin ﬁbroblasts ﬁnd ﬁndings ﬁrst ﬁve genetic globin globin chains globin genes globin mRNA Haematol haemo haemoglobin Hb F Heimpel Hempas heterozygotes histones homozygous Huehns human hybridization hypoxia increase incubation inﬂuence Ingram iron Lajtha late polychromatic lesion leukaemia liver lymphocytes malignancy marrow cells maturation mouse mRNA Najean Nathan normal nuclear membrane nucleus observed or-chain patients peripheral blood Peschle Polani precipitates precursors production proliferation protein ratio red cells reticulocytes serum signiﬁcant speciﬁc stem cell studies suggest syndrome synthesis technique thalassaemia therapy tion tissue transfused Verwilghen vitro Weatherall Wickramasinghe