Conjugation-Dependent Carcinogenicity and Toxicity of Foreign Compounds

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Academic Press, Jul 6, 1994 - Science - 519 pages
Each volume of Advances in Pharmacology provides a rich collection of reviews on timely topics. Emphasis is placed on the molecular basis of drug action, both applied and experimental.
Conjugation reactions have long been associated with the detoxification of xenobiotics. Recent studies suggest that Phase II reactions are an important mechanism for the bioactivation of xenobiotics.
This special volume of Advances in Pharmacology features a two-color dust jacket.

Summarizes the most recent information on:

  • Xenobiotic conjugation
  • Drug toxicity, hypersensitivity, and targeting
  • Chemical carcinogenesis
  • Glutathione-, sulfate conjugate-, and glucuranide conjugate-dependent toxicity
  • Bioactivation and bioconversion
 

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Contents

Chapter 1 Historical Perspectives on ConjugationDependent Bioactivation of Foreign Compounds
1
GlutathioneDependent Toxicity
17
Chapter 3 Enzymology of Cysteine SConjugate βLyases
71
Cysteine Conjugate βLyase Pathway
115
Chapter 5 Reversibility in GlutathioneConjugate Formation
163
Chapter 6 Glutathione Conjugation as a Mechanism for the Transport of Reactive Metabolites
183
Chapter 7 Metabolism and Genotoxicity of Dihaloalkanes
211
Chapter 8 Bioactivation of Thiols by OneElectron Oxidation
237
Chapter 9 Glutathione Mercaptides as Transport Forms of Metals
271
Sulfate ConjugateDependent Toxicity
299
Chapter 2 Carcinogen Activation by Sulfate Conjugate Formation
331
Glucuronide ConjugateDependent Toxicity
365
Bioactivation and Bioconversion
399
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About the author (1994)

Ferid Murad was born in Whiting, Indiana. Working concurrently on an M.D. and Ph.D. in Pharmacology, Dr. Murad graduated with both degrees from Case Western Reserve University, Cleveland, Ohio, in 1965. His many honors include the Alfred S. Maschke Award for Clinical Excellence from Case Western Reserve University in 1965. He has held several distinguished positions, including Acting Chairman in the Department of Medicine and Acting Division Chief, Division of Respiratory Medicine at Stanford University. He currently is CEO and President of Molecular Geriatrics Corporation in Lake Bluff, Illinois. Dr. Murad is married and has five children.

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