Conjugation-Dependent Carcinogenicity and Toxicity of Foreign Compounds
Academic Press, Jul 6, 1994 - Science - 519 pages
Each volume of Advances in Pharmacology provides a rich collection of reviews on timely topics. Emphasis is placed on the molecular basis of drug action, both applied and experimental.
Conjugation reactions have long been associated with the detoxification of xenobiotics. Recent studies suggest that Phase II reactions are an important mechanism for the bioactivation of xenobiotics.
This special volume of Advances in Pharmacology features a two-color dust jacket.
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Chapter 3 Enzymology of Cysteine SConjugate βLyases
Cysteine Conjugate βLyase Pathway
Chapter 5 Reversibility in GlutathioneConjugate Formation
Chapter 6 Glutathione Conjugation as a Mechanism for the Transport of Reactive Metabolites
Chapter 7 Metabolism and Genotoxicity of Dihaloalkanes
Chapter 8 Bioactivation of Thiols by OneElectron Oxidation
Chapter 9 Glutathione Mercaptides as Transport Forms of Metals
Sulfate ConjugateDependent Toxicity
Chapter 2 Carcinogen Activation by Sulfate Conjugate Formation
Glucuronide ConjugateDependent Toxicity
Bioactivation and Bioconversion
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acetylation activity acylase AdoMet amino acid aminoacylase Anders aromatic arylamines Ballatori bile bioactivation Biochem Biol Biophys Cancer Res carcinogen Carcinogenesis Carcinogenesis London catalyzed cDNA cells Chem chemical compounds conjugate covalent binding cysteine conjugate B-lyase cysteine S-conjugates cytosolic cytotoxic Dekant disulﬁde DNA adducts Drug effects electrophilic Elfarra enzymatic enzyme ethionine ethylene excretion Falany ﬁnding ﬁrst formation gene glucuronide glutamine glutamine transaminase glutathione conjugation glutathione S-transferase GSH conjugates GSTs Guengerich hamster hepatic hepatocytes human liver identiﬁed induced inhibition inhibitor isolated Ketterer kidney liver liver cytosol liver microsomes mechanism membrane mercapturic acid metabolism metabolites methyl methylmercury mice microsomal microsomal glutathione transferase Miller mutagenic N-acetyl nephrotoxicity nucleophiles ofthe oxidation pathway Pharmacol phenol phenol ST prodrugs protein proximal tubules puriﬁed rat kidney rat liver reaction reactive renal role signiﬁcant speciﬁc studies substrate sulfate sulfotransferase thiols thiyl radical tion tissues toxicity Toxicol transaminase transport tumors Vamvakas vitro vivo xenobiotics y-glutamyltransferase