Container Molecules and Their Guests
Container Molecules and Their Guests deals with the fundamental principles and objectives that govern this rapidly developing subject and illustrates the emergence of a new field of biomimetic chemistry. The book demonstrates how a number of techniques, such as molecular modelling, synthesis, crystal structure, NMR solution structure and mass spectral structure determinations can be combined to develop a new branch of organic chemistry. It discusses the chemistry of completely new families of complexes - the carceplexes, hemicarceplexes and velcraplexes - and reviews for the first time the uses of the interiors of hemicarceplexes as a new phase for carrying out chemical reactions and for protecting unstable species. Furthermore, it illustrates how complexation and decomplexation rates are measured to provide free energies of binding, discusses new phenomena such as constrictive binding, and shows how solvophobic forces drive complexation in a variety of organic solvents. It also covers catalysis through complexation and chiral recognition in catalysis, both secondary themes of this volume. Container Molecules and Their Guests will provide stimulating reading for researchers, post-graduate students and teachers involved in bio-organic chemistry, organic chemistry, materials science, and medicinal and pharmaceutical chemistry.
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Contexts Conceptions Corands
Spherands Spheraplexes and Their
Chiral Recognition in Complexation
Partial Enzyme Mimics
Factors on Structure
Vases Kites Velcrands and Velcraplexes
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acid anisyl aryl atoms axis benzene binaphthyl binding free energies bridges C.B. Knobler carbonyl carceplexes carcerand cavitands cavity CH3 CH3 CH3CN CH3OH Chart Chem chiral chiral recognition complexes compounds conformation contacts containing corand CPK models CPK molecular model crystal structure cyclobutadiene D.J. Cram decomplexation diastereomeric dibenzofuran dimer dissolved distances enantiomers enthalpy entropy equatorial ester four free energies gave H NMR H2C H2C H2C hemicarceplexes hemicarcerand hemispherands hemispheres HNMR host and guest host-guest host-s hydrogen bonds incarcerated inner phase ions kcal mol ligating methyl groups Molecular model Molecular model examination molecules monomer NMR spectra nucleophile o-clock OCH2O octols organic oxygens picrate plane polar caps portals preorganized produced protons pyrazine pyridine R.C. Helgeson racemic rate constants reaction respectively ring rotations Section shell closure signals solution solvation solvent spectrum spherands stereoview steric structural recognition substituted symmetry syntheses temperature transition tripodal binding unshared electron pairs upfield yield