Contemporary Targeted Therapies in Rheumatology

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Josef S. Smolen, Peter E. Lipsky
CRC Press, Oct 18, 2007 - Medical - 618 pages
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Targeted therapies of rheumatic diseases have become a reality and have completely changed patient care as well as patient expectations. Initial success with therapies aimed at blocking TNF and IL-1 has stimulated the development of additional targeted approaches focused on other cytokines as well as specific cells and pathways involved in the pathogenesis of rheumatic diseases.Along with the clinical success of some of these targeted approaches, new information has been generated from their application concerning the pathophysiologic mechanisms underlying rheumatic diseases and, as a result, new targets have been identified.The ongoing dialogue between basic scientists, clinical investigators, metrologists and clinicians remains an essential component for the further development, refinement, integration and optimization of targeted therapies of the rheumatic diseases. The goal of this volume is to provide comprehensive, up to date information on all aspects of the rapidly evolving development of targeted therapies of the rheumatic diseases to foster further advances to improve therapy of patients with these conditions.

Targeted Therapies in Rheumatology established itself as an excellent reference for all those needing to know about the clinical implications of new drugs and developments for patients suffering from rheumatoid arthritis. This volume takes up the further developments that have occurred in several of the drug therapies covered in the first volume, as well as looking at the latest areas of promising research.

 

 

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Contents

Chapter 1 T cells overview update
1
Chapter 02
7
Chapter 3 Regulatory T cells
23
Chapter 4 Bcell antigen receptor signaling and autoimmunity
31
Chapter 5 Macrophages in rheumatoid arthritis
45
Chapter 6 Dendritic cells
63
Chapter 7 Osteoclasts
79
Chapter 8 Cell contact dependence of inflammatory events
85
Chapter 27 Complement and pregnancy loss
339
Chapter 28 Matrix metalloproteinases
353
Chapter 29 MMPs and ADAMs as targets for therapies in arthritis
367
Chapter 30 Update on proinflammatory cytokine blockade in rheumatoid arthritis
385
Chapter 31 Targeting interleukin1 in rheumatic diseases
391
Chapter 32 Update on targeted therapy in psoriatic arthritis
401
Chapter 33 Spondyloarthritides
413
Chapter 34 Early Arthritis
419

possible targets for novel treatments for rheumatoid arthritis
105
a new therapeutic target in inflammatory arthritis
121
Chapter 11 TNFα
133
Chapter 12 Update on interleukin6
149
Chapter 13 Interleukin13
159
Chapter 14 Biology of interleukin15
175
a new target in arthritis
185
Chapter 16 The role of interleukin18 in inflammation
195
Chapter 17 Interleukin21
211
Chapter 18 The biology of human interleukin32
225
Chapter 19 The interferons
231
Chapter 20 Osteoprotegerin
251
inflammatory angiogenic and homeostatic chemokines and their receptors
265
Chapter 22 New developments in NFkB
285
Chapter 23 Roles of the JAKSTAT signaling pathways in rheumatoid arthritis
297
Chapter 24 Suppressor of cytokine signaling SOCSproteins as therapeutic targets in rheumatoid arthritis
305
Chapter 25 Wnt signaling for targeted therapies in rheumatology
317
update on cyclooxygenases and prostaglandin synthases
329
Chapter 35 Juvenile arthritis
425
Chapter 36 Update systemic lupus erythematosus
435
Chapter 37 Vasculitis
449
Chapter 38 Myositis
467
Chapter 39 TNF blockade in orphan rheumatic diseases
485
Chapter 40 Overview of the safety of TNF inhibitors
497
Chapter 41 AntiCD20 to further targeted therapies in rheumatology
509
a therapeutic promise waiting to be fulfilled
527
Chapter 43 AntiCD3 antibody a history of successful immune interventions
543
Chapter 44 Alefacept
553
Chapter 45 Clinical targeting of interleukin15
561
Chapter 46 Clinical prospects of MAPK inhibitors
569
Chapter 47 Clinical prospects of NFκB inhibitors to further targeted therapies in rheumatology
581
Chapter 48 Outcomes assessment in rheumatic disease
601
Index
617
Back Cover
635
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