Control of Biofilm Infections by Signal Manipulation
Springer Science & Business Media, Nov 28, 2007 - Medical - 175 pages
In the well-watered groves of academe, most of us are content to gather worshipful students and technicians in a shady nook to contemplate the eternal verities and to plan extravagant feasts to celebrate our contributions to “knowledge” and to the gradual improvement of the human condition. As one convocation follows another, and as our funding agencies pump billions of dollars into incremental research that ?lls every possible pigeon-hole in which a gene makes a protein, a small number of intellectual athletes seize a pivotal concept and plunge into the real world. It is this small band of nimble and impossibly brave intellectual halfbackswho win gamesin the real world, and this book is the result of the drive and intellectual athleticism of its editor and several of her contributors. Bacteria affect humans more than any other life forms with which we share the blue planet, but our understandingof these invisible companionshas developed in a staggering pattern, crippled by our panic and consequent shifts of emphasis. When our race was threatened by epidemic diseases, we visualized bacteria as swarms of potentially lethal planktoniccells from which we must remain isolated by sanitation and which we had to kill by immunization and chemical antibacterial compounds. By the time this overriding threat had been obviated, we began to examine na- ral and pathogenic ecosystems by direct methods, and we were surprised to ?nd that planktonic bacteria are comparatively rare and that most prokaryotes grow in matrix-enclosedbio?lms.
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Detection In Vitro of QuorumSensing Molecules and Their Inhibitors
QuorumSensing Inhibitory Compounds
Mathematical Modeling of QuorumSensing Control in Bioﬁlms
Animal Models Commonly Used to Study QuorumSensing Inhibitors
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Acad Sci USA activity aeruginosa biofilm AHL signal anti-AHL anti-LasR antibiotics antimicrobial Appl Environ Microbiol autoinducer bacteria Bacterial biofilms Bacteriol bacterium biofilm development biofilm formation biofilm growth biofilm infections Biol catheter cell fraction Chem chronic wounds Cirioni coli compounds concentration Costerton JW cystic fibrosis Dell’Acqua downregulated Eberl effect encoding enzymes Escherichia coli furanone gene expression Giacometti Givskov graft gram-negative gram-positive Greenberg EP Hentzer homoserine lactone Infect Immun inhibition iron Kjelleberg Korem lactoferrin lungs Manefield mice Microbiology Mocchegiani F Mol Microbiol motility mutant Natl Acad Sci Parsek pathogen patients peptide planktonic Proc Natl Acad production protein Pseudomonas aeruginosa pyoverdine QS system quorum sensing quorum-sensing inhibitors Rasmussen TB receptor regulator resistance RNAIII Scalise G siderophores signal molecules specific Staphylococcus aureus strains Streptococcus Streptococcus mutans studies surface synthesis target tobramycin transcriptional TRAP upregulated cells virulence factors vivo