Controlled Pulmonary Drug Delivery

Front Cover
Hugh D.C. Smyth, Anthony J. Hickey
Springer Science & Business Media, Jun 24, 2011 - Medical - 558 pages

The pace of new research and level of innovation repeatedly introduced into the field of drug delivery to the lung is surprising given its state of maturity since the introduction of the pressurized metered dose inhaler over a half a century ago. It is clear that our understanding of pulmonary drug delivery has now evolved to the point that inhalation aerosols can be controlled both spatially and temporally to optimize their biological effects. These abilities include controlling lung deposition, by adopting formulation strategies or device technologies, and controlling drug uptake and release through sophisticated particle technologies. The large number of contributions to the scientific literature and variety of excellent texts published in recent years is evidence for the continued interest in pulmonary drug delivery research. This reference text endeavors to bring together the fundamental theory and practice of controlled drug delivery to the airways that is unavailable elsewhere. Collating and synthesizing the material in this rapidly evolving field presented a challenge and ultimately a sense of achievement that is hopefully reflected in the content of the volume.

 

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Contents

Macro and Microstructure of the Airways for Drug Delivery
1
Pulmonary Drug Metabolism Clearance and Absorption
21
Pulmonary Drug Delivery An Historical Overview
51
The Physics of Aerosol Droplet and Particle Generation from Inhalers
75
Overcoming Lung Clearance Mechanisms for Controlled Release Drug Delivery
101
Targeted Drug Delivery Through the Respiratory System Molecular Control on Lung Absorption and Disposition
127
Controlled Transport for Pulmonary Drug Delivery
143
Chapter 8 Science and Technology of Pressurized MeteredDose Inhalers
164
Chapter 14 Liposomes for Pulmonary Drug Delivery
313
Chapter 15 Nanoparticles for Pulmonary Delivery
335
Chapter 16 Pulmonary Delivery of Plasmid DNA for Disease Prevention and Therapy
367
Chapter 17 In Vitro Performance Testing for Pulmonary Drug Delivery
383
Chapter 18 In Vitro Cell Culture Models for Evaluating Controlled Release Pulmonary Drug Delivery
416
Chapter 19 In Vivo Animal Models for ControlledRelease Pulmonary Drug Delivery
443
Chapter 20 Imaging Pulmonary Drug Delivery
475
A US Regulatory Science Perspective
489

Chapter 9 Science and Technology of Dry Powder Inhalers
203
Science and Technology of Nebulizers and LiquidBased Aerosol Generators
223
Excipients Utilized for Modifying Pulmonary Drug Release
237
Chapter 12 Polymers for Pulmonary Drug Delivery
264
Chapter 13 Particle Engineering Technologies for Pulmonary Drug Delivery
283
Developing Performance Specifications for Pulmonary Products
529
About the Editors
544
Index
545
Copyright

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About the author (2011)

Dr. Hugh Smyth is Assistant Professor of Pharmaceutics at the University of Texas, Austin. He is a recipient of the Young Investigator in Pharmaceutics and Pharmaceutical Technology Award of the American Association of Pharmaceutical Scientists and has edited a volume on pulmonary drug delivery. Drs. Hickey and Smyth share a research interest in the delivery of drugs to the lungs for the treatment and prevention of a number of diseases.

Dr. Anthony Hickey is Professor of Molecular Pharmaceutics and Biomedical Engineering at the University of North Carolina at Chapel Hill. He is a fellow of the Institute of Biology, American Association of Pharmaceutical Scientists and the American Association for the Advancement of Science. He has published several edited and authored volumes in the fields of pharmaceutical aerosols, process engineering and particulate science.

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