Cooperation of Liver Cells in Health and Disease: With 18 Tables
It is only during the last decade that the functions of sinusoidal endothelial cells, Kupffer cells, hepatic stellate cells, pit cells and other intrahepatic lymphocytes have been better understood. The development of methods for isolation and co-culturing various types of liver cells has established that they communicate and cooperate via secretion of various intercellular mediators. This monograph summarizes multiple data that suggest the important role of cellular cross-talk for the functions of both normal and diseased liver. Special features of the book include concise presentation of the majority of detailed data in 19 tables. Original schemes allow for the clear illustration of complicated intercellular relationships. This is the first ever presentation of the newly emerging field of liver biology, which is important for hepatic function in health and disease and opens new avenues for therapeutic interventions.
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acid activated stellate cells antigen apoptosis Biol blood cell types cellular collagen cytokines cytotoxic effects eicosanoids endothelin-1 endotoxemia endotoxin enzyme extracellular matrix fat-storing cells fibrogenesis Friedman function Gastroenterology gene expression glucose Gressner hepatic sinusoidal hepatic stellate cells hepatocyte growth factor Hepatol Hepatology human liver IGF-I Immunol increased induce inflammatory inhibition intercellular interleukin-6 isolated Ito cells Jungermann Kawada Knittel Kupffer cells leukotrienes lipocytes liver fibrosis liver injury liver lobule liver macrophages liver sinusoids lymphocytes macrophages mediators metabolism modulation molecules mRNA neutrophils nitric oxide nonparenchymal liver cells normal liver paracrine parenchymal cells parenchymal liver cells perfused perisinusoidal PGE2 phenotype Physiol Pinzani pit cells portal production proliferation prostaglandin prostanoids quiescent Ramadori G rat hepatic stellate rat hepatocytes rat Kupffer cells rat liver receptor regulation release response retinoids retinol role secretion shown sinusoidal endothelial cells stimulated synthesis TGF-P tissue TNF-a transforming growth factor tumor necrosis upregulation uptake vitamin vitro vivo Wisse