Coronary Vasculature: Development, Structure-Function, and Adaptations

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Springer Science & Business Media, Oct 19, 2012 - Medical - 278 pages
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Ischemic heart disease is the leading cause of morbidity and mortality in the developed world. The high metabolism and oxygen demand of the cardiac myocardium depends on both a high blood flow and a rich capillary density. For this reason, the growth of the coronary vasculature is vital, not only in early development, but also in the adult faced with various stresses. Novel technologies have enabled the discovery of the molecular mechanisms underlying the growth and assembly coronary vessels, and this volume covers the hierarchy of the coronary vasculature from its embryonic origins through its postnatal growth, adulthood, and senescence. Chapters address normal coronary development, coronary anomalies and their possible underlying developmental errors, coronary vessel adaptations to exercise training, aging, hypoxia, myocardial ischemia, and cardiac hypertrophy.

This comprehensive overview of current research in coronary vessels and myocardial perfusion was written by Dr. Robert J. Tomanek, Emeritus Professor of Anatomy and Cell Biology at the University of Iowa. The book reviews, discusses, and integrates findings from various areas of coronary vasculature research, and as a result, will be a valuable reference source for cardiovascular scientists and physicians for many years to come.

 

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Contents

1 General Concepts of Blood Vessel Formation and Remodeling
1
2 Prenatal Coronary Morphogenesis
25
3 Postnatal Coronary Morphogenesis and Growth
47
4 StructureFunction of the Coronary Hierarchy
59
5 Historical Perspectives
83
6 Coronary Anomalies
101
7 Aging
122
8 Adaptations to Exercise Training
143
9 Hypoxia
166
10 Myocardial Ischemia and Infarction
189
11 Cardiac Hypertrophy
221
12 Therapy for the Coronary Circulation
247
Index
267
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About the author (2012)

Robert J. Tomanek, PhD, is Professor Emeritus, Anatomy and Cell Biology, Carver College of Medicine, University of Iowa, Iowa City.

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