M. Lai, Stephen A. Stohlman
Springer US, 1987 - Medical - 591 pages
Coronaviruses have emerged during the past ten years from being a group of viruses causing a variety of minor veterinary and human diseases to a major virus group of both clinical significance and molecular biological interest. Against this background, two international coronavirus symposia were held in 1980 and 1983. In recent years, the pace of coronavirus research has been quickened even more by infusion of recombinant DNA technology and establishment of various animal model systems to study the pathogenesis and immunology of coronavirus infections. We therefore organized the Third International Coronavirus Symposium held at Asilomar, California in September 1986, which was attended by more than 120 participants representing a cross section of both academia and industry. This symposium provided an exciting and stimulating forum for assessing the progress made since the last triennial symposium in Netherlands and to suggest the directions for future efforts. This volume collects the scientific papers presented in this symposium. Three loosely defined areas, Molecular biology, Virus-Cell Interaction and Viral Pathogenesis, are separated. These papers very nicely summarize the current status of coronavirus research. They contain a large amount of sequence data, including the complete sequence of a 27 Kb coronavirus genome, a novel mechanism of mRNA synthesis that is unique to coronviruses, and many exciting aspects of coronavirus pathogenesis and immunology. Reflecting the growing interest in the preparation of vaccines, several papers also address the issues related to coronavirus vaccines, which is an area new to this symposium. Dr.
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Coronaviruses a Historical Perspective
Molecular Biology of Coronaviruses 1986
The Complete Nucleotide Sequence of Avian Infectious Bronchitis
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activity amino acid animals antigen assay astrocytes BALB/c brain cats cDNA cDNA clones cell cultures cell lines DBT cells demyelinating disease detected encephalomyelitis epitopes feline feline infectious peritonitis FIPV gene genetic genome genomic RNA glial glycoprotein homology Immunol incubated induced infected cells inoculated intracellular isolated JHM virus JHMV JHMW L-2 cells leader RNA lymphocytes lysates MAbs macrophages membrane Meulen MHV-infected MHV-JHM MHV3 mice molecular weight monoclonal antibodies mouse hepatitis virus mRNA murine coronavirus mutants neurons neutralization nucleocapsid nucleotides oligodendrocytes oligonucleotide pathogenesis pathogenicity Pedersen peplomer peplomer protein plaque polymerase polypeptide protein purified rats recombinants region replication resistant sequence serum shown Siddell specific Stohlman strain structure studies Sturman subgenomic supernatants susceptible Table TGE virus TGEV TGEW tissue titers transcription transmissible gastroenteritis transmissible gastroenteritis virus vaccine variants virions Virol Virology virulent virus infection viruses vitro vivo Wege YAC-MHV3