Cortical Development: Genes and Genetic Abnormalities

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Novartis Foundation
John Wiley & Sons, Feb 28, 2008 - Science - 302 pages
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To understand the brain and its devastating diseases, we need to reveal the mechanisms that produce it and the ways in which it can constantly change throughout a lifetime.  This book features a timely and insightful discussion between developmental neurobiologists and clinicians who deal with disorders of the nervous system.

Chapters in this book deal specifically with cell fate determination, cell migration and disorders of cell migration; current concepts and new ideas about cortical arealisation, and disorders which can arise from incorrect arealisation; genes implicated in the development of cortical connectivity and related pathologies such as schizophrenia and synaesthesia; and susceptibility genes for cognitive disorders such as schizophrenia, autism, dyslexia, and attention deficit disorder.

 

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Contents

GENES AND GENETIC ABNORMALITIES Chairs introduction
1
GENES AND GENETIC ABNORMALITIES Molecular development of corticospinal motor neuron circuitry
3
GENES AND GENETIC ABNORMALITIES Perspectives on the developmental origins of cortical interneuron diversity
21
GENES AND GENETIC ABNORMALITIES Genetic determinants of neuronal migration in the cerebral cortex
45
GENES AND GENETIC ABNORMALITIES Neural stem and progenitor cells in cortical development
59
GENES AND GENETIC ABNORMALITIES Genes that control the size of the cerebral cortex
79
GENES AND GENETIC ABNORMALITIES General Discussion I
96
GENES AND GENETIC ABNORMALITIES Control of cortical neuron layering lessons from mouse chimeras
99
GENES AND GENETIC ABNORMALITIES Genetic regulation of prefrontal cortex development and function
165
GENES AND GENETIC ABNORMALITIES Selforganization and pattern formation in primate cortical networks
178
GENES AND GENETIC ABNORMALITIES Molecular mechanisms of thalamocortical axon targeting
199
GENES AND GENETIC ABNORMALITIES Genes involved in the formation of the earliest cortical circuits
212
GENES AND GENETIC ABNORMALITIES Emx and Nfi genes regulate cortical development and axon guidance in the telencephalon
230
GENES AND GENETIC ABNORMALITIES Schizophrenia susceptibility genes and their neurodevelopmental implications focus on neuregulin 1
246
GENES AND GENETIC ABNORMALITIES Focal brain malformations a spectrum of disorders along the mTOR cascade
260
GENES AND GENETIC ABNORMALITIES Final Discussion
276

GENES AND GENETIC ABNORMALITIES Intracortical multidirectional migration of cortical interneurons
116
GENES AND GENETIC ABNORMALITIES The atypical cadherin Celsr3 regulates the development of the axonal blueprint
130
GENES AND GENETIC ABNORMALITIES Regulation of laminar and area patterning of mammalian neocortex and behavioural implications
141

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