Corynebacteria: Genomics and Molecular Biology

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Andreas Burkovski
Horizon Scientific Press, 2008 - Science - 340 pages
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Corynebacteria are a diverse group Gram-positive bacteria found in a range of different ecological niches such as soil, vegetables, sewage, skin, and cheese smear. Some, such as Corynebacterium diphtheriae, are important pathogens while others, such as Corynebacterium glutamicum, are of immense industrial importance. In fact, C. glutamicum is one of the biotechnologically most important bacterial species in use today with an annual production of more than two million tons of amino acids, mainly L-glutamate and L-lysine. Due to its industrial importance, C. glutamicum has been studied extensively over the years, and the publication of the C. glutamicum genome sequence in 2003 provided renewed impetus to these studies. To date, the complete genome sequences of four different species have been published, and sequencing of at least two more species is ongoing. These genomic data have enabled a dramatic improvement in our understanding of the corynebacterial genome architecture, metabolic processes, species-specific traits, industrial capabilities, and potential roles in pathogenicity of humans and animals. In addition, these genome sequences, allied with newly developed genetic tools, will consolidate C. glutamicum as a model organism for systems biology. Research in this area has never been more exciting. This volume brings together leading experts to provide a description of the current state-of-the-art molecular biology toolbox available for Corynebacterium research, including global analyses techniques such as comparative genomics, transcriptome, proteome, and metabolome analysis, as well as the most recent knowledge on Corynebacterium promoter structures and vector systems. Furthermore, topics such as regulatory networks controlling carbon, nitrogen, phosphorus, sulphur and iron metabolism, cell wall structure, proteolysis, and environmental stress response are covered. The book will be essential reading for all Corynebacterium scientists and everyone with an interest in global analysis techniques, global regulation, and òsystems biology.
 

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Contents

The Discovery of Corynebacterium glutamicum and Birth of Amino Acid Fermentation Industry in Japan
1
Genomics of Industrially and Medically Relevant Corynebacteria
7
DNA Microarraybased Transcriptome Analysis in C glutamicum
33
Proteomics of Corynebacterium glutamicum and Other Corynebacteria
55
Metabolic Network Analysis and Design in Corynebacterium glutamicum
79
Plasmids and Promoters in Corynebacteria and Their Applications
113
Regulation of Carbon Metabolism in Corynebacterium glutamicum
155
Molecular Mechanisms of Nitrogen Control in Corynebacteria
183
Phosphorus Metabolism and its Regulation
203
Sulfur Metabolism in Corynebacterium glutamicum
217
Regulation of Iron Homeostasis in Corynebacterium glutamicum
241
Structure and Synthesis of the Cell Wall
267
General and Regulatory Proteolysis in Corynebacteria
295
Environmental Stress Response of Corynebacterium glutamicum
313
Index
335
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