Crystallography Made Crystal Clear: A Guide for Users of Macromolecular Models

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Academic Press, Dec 2, 2012 - Science - 202 pages
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Crystallography Made Crystal Clear is designed to meet the need for an X-ray analysis that is between brief textbook sections and complete treatments. The book provides non-crystallographers with an intellectually satisfying explanation of the principles of how protein models are gleaned from X-ray analysis. The understanding of these concepts will foster wise use of the models, including the recognition of the strengths and weaknesses of pictures or computer graphics. Since proteins comprise the majority of the mass of macromolecules in cells and carry out biologically important tasks, the book will be of interest to biologists.


Provides accessible descriptions of principles of x-ray crystallography, built on simple foundations for anyone with a basic science background
Leads the reader through clear, thorough, unintimidating explanations of the mathematics behind crystallography
Explains how to read crystallography papers in research journals
If you use computer-generated models of proteins or nucleic acids for:
Studying molecular interactions
Designing ligands, inhibitors, or drugs
Engineering new protein functions
Interpreting chemical, kinetic, thermodynamic, or spectroscopic data
Studying protein folding
Teaching macromolecule structure,and if you want to read new structure papers intelligently; become a wiser user of macromolecular models; and want to introduce undergraduates to the important subject of x-ray crystallography, then this book is for you.
 

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Contents

Chapter 1 Model and Molecule
1
Chapter 2 An Overview of Protein Crystallography
5
Chapter 3 Protein Crystals
29
Chapter 4 Collecting Diffraction Data
43
Chapter 5 From Diffraction Data to Electron Density
83
Chapter 6 Obtaining Phases
101
Chapter 7 Obtaining and Judging the Molecular Model
131
Chapter 8 A Users Guide to Crystallographic Models
157
Chapter 9 Tools for Studying Proteins
185
Index
199
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About the author (2012)

Gale Rhodes earned a B.S. in applied mathematics at North Carolina State University, and then a Ph.D. in Chemistry at the University of North Carolina. He is currently a professor of chemistry at the University of Southern Maine, Portland. His main duty, and first love, is teaching undergraduate biochemistry. He has received awards for outstanding teaching at three different colleges. His best known publication is the first edition of Crystallography Made Crystal Clear, which received very complimentary reviews in several journals. He has also published three book chapters, three book reviews, and about 30 articles on diverse subjects, including research articles in biochemistry, and articles on chemistry, science, and interdisciplinary education.

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