Crystallography Made Crystal Clear: A Guide for Users of Macromolecular Models
Crystallography Made Crystal Clear is designed to meet the need for an X-ray analysis that is between brief textbook sections and complete treatments. The book provides non-crystallographers with an intellectually satisfying explanation of the principles of how protein models are gleaned from X-ray analysis. The understanding of these concepts will foster wise use of the models, including the recognition of the strengths and weaknesses of pictures or computer graphics. Since proteins comprise the majority of the mass of macromolecules in cells and carry out biologically important tasks, the book will be of interest to biologists.
Provides accessible descriptions of principles of x-ray crystallography, built on simple foundations for anyone with a basic science background
Leads the reader through clear, thorough, unintimidating explanations of the mathematics behind crystallography
Explains how to read crystallography papers in research journals
If you use computer-generated models of proteins or nucleic acids for:
Studying molecular interactions
Designing ligands, inhibitors, or drugs
Engineering new protein functions
Interpreting chemical, kinetic, thermodynamic, or spectroscopic data
Studying protein folding
Teaching macromolecule structure,and if you want to read new structure papers intelligently; become a wiser user of macromolecular models; and want to introduce undergraduates to the important subject of x-ray crystallography, then this book is for you.
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ALBP amino-acid amplitude anomalous scattering asymmetric unit backbone bond lengths calculated Chapter conformation contains coordinates crystalline crystallographic model data collection data set deﬁned described diffraction data diffraction pattern display edges electron density electron-density map Equation Fhkl ﬁgure ﬁle ﬁlm ﬁnd ﬁnding ﬁrst ﬁt Fourier series Fourier transform give graphics heavy atom heavy-atom derivatives improve lattice point ligand measurable reﬂections methods molecular model molecules orientation origin parameters Patterson atoms Patterson function Patterson map peaks periodic function phase estimates phasing model produce programs protein crystals R-factor reciprocal lattice reciprocal space reciprocal-lattice point reﬁned reﬁnement reﬂection hkl reﬂection intensities reﬂections residues resolution result rotation screw axis Section set of planes side chains solution space group speciﬁc sphere of reﬂection structure determination structure factors surface symmetry elements temperature factors term three-dimensional tion unit cell values vector viewer wave wavelength x-ray beam