Current Perspectives in microRNAs (miRNA)

Front Cover
Shao-Yao Ying
Springer Science & Business Media, Sep 12, 2008 - Medical - 464 pages
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Nearly 97% of the human genome is the non-coding DNA, which varies from one species to another, and changes in these sequences are frequently noticed to manifest clinical and circumstantial malfunction. Numerous non-protein-coding genes are recently found to encode microRNAs, which are responsible for RNA-mediated gene silencing through RNA interference (RNAi)-like pathways. MicroRNAs (miRNAs), small single-stranded 17–25 nucleotide RNAs capable of interfering with intracellular messenger RNAs (mRNAs) that contain either complete or partial complementarity, are useful for the design of new therapies against cancer polymorphism and viral mutation. Currently over 1000 native miRNA species found in vertebrates and many more new miRNA homologs continue to be identified; however, most of their functions remain to be determined. In this book, many new perspectives of the miRNA research are reviewed and discussed, including their roles in stem cell maintenance, embryonic development, tissue differentiation, adult physiology, disease pathology, cancer research, viral infection, genetic engineering in plants, and utility in cosmetic applications. These new findings may not only provide significant insight into the various mechanisms of miRNAs but also offer a great opportunity in developing new therapeutic interventions.

 

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Contents

Ying Ch01pdf
1
Ying Ch02pdf
17
Ying Ch03pdf
35
Ying Ch04pdf
51
Ying Ch05pdf
73
Ying Ch06pdf
97
Ying Ch07pdf
118
Ying Ch08pdf
129
Ying Ch14pdf
245
Ying Ch15pdf
267
Ying Ch16pdf
283
Ying Ch17pdf
305
Ying Ch18pdf
322
Ying Ch19pdf
349
Ying Ch20pdf
367
Ying Ch21pdf
385

Ying Ch09pdf
145
Ying Ch10pdf
167
Ying Ch11pdf
186
Ying Ch12pdf
205
Ying Ch13pdf
225
Ying Ch22pdf
394
Ying Ch23pdf
431
Ying Indexpdf
461
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