Cytokines and Bone Metabolism
Cytokines and Bone Metabolism presents a comprehensive review of the research done to date on the role of cytokines in bone metabolism. All of the major groups of cytokines and growth factors are covered, and more than 2,000 references are included. In each chapter, the biochemistry and wider cellular actions of individual factors are reviewed before data detailing the in vitro and in vivo actions in bone are presented. Extensive reviews of the cell biology of bone, the potential role of cytokines in bone diseases, and the theoretical and practical possibilities for pharmacological intervention based on cytokines as targets are also provided. Cytokines and Bone Metabolism is an indispensable reference for researchers and students in a wide range of medical fields.
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A Bone Resorption
Systemic and Local Factors Which Regulate Bone Cell
The Regulation of Bone Remodeling
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Abstr Acad activity amino acid antibodies binding Biochem Biol biological Biophys bone cells bone formation bone marrow bone resorption bradykinin Calcif calcitonin calcium cartilage cell line Chem Clin cloning collagen collagen synthesis colony stimulating factor cultures cytokines differentiation Endocrinol Endocrinology epidermal growth factor expression fetal rat fibroblast growth factor gene GM-CSF hematopoietic human hypercalcemia IGF-I IGFBPs Immunol increased induced inhibitor inhibits insulin insulin-like growth factor interferon interleukin isolated macrophages mediated metabolism Mineral mitogen molecule monocytes mouse calvaria mRNA Mundy murine Natl osteoblast-like cells osteoblastic cells osteoclast osteoporosis osteosarcoma osteosarcoma cells parathyroid hormone parathyroid hormone-related PDGF peptide phosphatase platelet-derived growth factor potential precursor Proc production proliferation prostaglandin protein PTHrP purified Raisz receptors recombinant regulation release resorbing resorption in vitro response Rodan role sequence serum stimulates bone resorption stromal cells TGF-o TGF8 thrombin Tiss tissue transforming growth factor tumor necrosis factor vivo