Cytokines and B Lymphocytes
Robin E. Callard
Academic Press, Dec 2, 2012 - Medical - 288 pages
Over the past five years the major importance of cytokines in the regulation of the immune system has become established. This book is the first to review the role of these factors in the control of growth of differentiation of B lymphocytes and thus represents an up-to-date and timely overview of the B-cell response.
For the immunologist, there are detailed accounts of the physio-chemical properties of the relevant cytokines and their effect on B lymphocytes from the level of receptor signalling, through ontogeny, activation and proliferation to the expression of specific immunoglobulin isotypes. For the clinician, the involvement of cytokines in disease and normal immune response is discussed.
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Chapter 3 Receptor signalling in Β lymphocytes
Chapter 4 Rôle of cytokines in the ontogeny activation and proliferation of Β lymphocytes
Chapter 5 Cytokine regulation of Bcell differentiation
Chapter 6 Collaboration between Τ and Β cells
Chapter 7 Immunoglobulin isotype regulation
Acad activated B cells afﬁnity amino acids anti-IgM antibody responses antigen antigen-speciﬁc Arai assays autocrine B-cell Banchereau binding Callard Cambier cell activation cell growth cell lines cell proliferation cell types class II molecules co-stimulation Coffman culture cysteine cysteine residues cytokines Defrance effect enhance expression Fauci ﬁndings Finkelman ﬁrst function genes glycosylation Glycosylation sites Gordon growth factor Harada helper cells Hirano human B cells hyper-IgE syndrome identiﬁed IFN-y Ig secretion IgE production IgE synthesis IgG1 IgG2a IL-2 receptor IL-4 induced immune Immunol inhibited inhibitory Interferon Interleukin intracellular Kehrl Kishimoto Lipsky LMW BCGF lymphocytes lymphokines MHC class II mice mitogenic molecular Mosmann murine murine B cells Natl normal B cells Ohara patients polyclonal Proc protein puriﬁed recently resting B cells role Romagnani shown signal transduction Snapper soluble speciﬁc studies supernatants surface T—B cell Takatsu TCCs TGF-ﬂ TH cells TNF-a Vitetta vitro vivo