Cytokines and B Lymphocytes

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Robin E. Callard
Academic Press, Dec 2, 2012 - Medical - 288 pages
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Over the past five years the major importance of cytokines in the regulation of the immune system has become established. This book is the first to review the role of these factors in the control of growth of differentiation of B lymphocytes and thus represents an up-to-date and timely overview of the B-cell response.
For the immunologist, there are detailed accounts of the physio-chemical properties of the relevant cytokines and their effect on B lymphocytes from the level of receptor signalling, through ontogeny, activation and proliferation to the expression of specific immunoglobulin isotypes. For the clinician, the involvement of cytokines in disease and normal immune response is discussed.
 

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Contents

Chapter 2 The physicochemical properties of Β cell growth and differentiation factors and their receptors
11
Chapter 3 Receptor signalling in Β lymphocytes
39
Chapter 4 Rôle of cytokines in the ontogeny activation and proliferation of Β lymphocytes
65
Chapter 5 Cytokine regulation of Bcell differentiation
115
Chapter 6 Collaboration between Τ and Β cells
143
Chapter 7 Immunoglobulin isotype regulation
173
Chapter 8 Autocrine aspects of the Β lymphocyte response
195
Chapter 9 Cytokine action on Β cells in disease
215
Chapter 10 Β Cell assays for growth and differentiation factors
253
Index
267
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