Cytokines in Human Reproduction
Joseph A. Hill
Wiley, 2000 - Medical - 341 pages
The role of cytokines in the pathogenesis of disease is an area of research offering exciting challenges for scientists developing new disease interventions. Cytokines are proteins secreted by immune and inflammatory cells that circulate in the blood or extracellular space and bind to specific receptors activating a cascade of intracellular signals, which ultimately affect the growth, differentiation, and viability of cells. The effect of too little or too much of an individual cytokine or cytokines as a potential source of disease has led to novel treatment strategies designed to control the processes affecting cytokine levels.
Cytokines in Human Reproduction is the first reference to examine the role and effect of cytokines in reproduction, specifically how they cause (and prevent) disease. Edited by one of the foremost authorities in reproductive immunology, this important work includes the latest in cytokine research from leading specialists. In its thirteen chapters the book includes discussion of cytokines in both testicular and ovarian function, cytokines in early pregnancy, cytokines in disease development (uterine leiomyomas and tumors) as well as:
* The role of psycho-neuro-endocrine immunology in reproduction
* Cytokine networks in the human placenta
* Cytokines in the human fallopian tube
* Cytokines in the peritoneal environment
* Cytokines in endometriosis
* Oncogenes and growth factors in gynecologic oncology
Authoritative and up-to-date, Cytokines in Human Reproduction offers the first comprehensive look at cytokines in reproductive science and is a valuable resource in the library of the maternal-fetal specialist, reproductive immunologist, obstetrician/gynecologist as well as researcher or student.
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Cytokines and Testicular Function
Cytokines in Ovarian Function
Cytokines in the Cervical Vaginal Environment
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activity amniotic fluid antigen binding Biol Reprod carcinoma cell lines cell types cellular cervical chemokines concentrations corpus luteum cultures cytokines decidual detected differentiation effects embryo Endocrinology endometrial stromal cells endometriosis endometrium epidermal growth factor epithelial cells estrogen fallopian tube Fertil Steril fibroblasts follicles follicular function GM-CSF granulosa cells Gynecol hormone human endometrium Human Reprod IFN-y IGF-I immune implantation increased induced infection infertility inflammatory inhibits insulin-like growth factor interaction interleukin-1 leiomyomas leukocytes levels Leydig cells lymphocytes macrophages mediated membrane menstrual cycle mice mitogenic modulation monocytes mRNA myometrial myometrium normal ObstetGynecol ovarian cancer ovary patients PDGF peritoneal fluid phase placenta plasma pregnancy preterm labor production progesterone prostaglandin protein receptor regulation reproductive response role secretion serum smooth muscle cells steroidogenesis stimulates stromal cells studies synthesis testicular TGF-B TGF-o tion tissue TNF-o transforming growth factor trophoblast tumor necrosis factor uterine VEGF Viable vitro women with endometriosis