Cytokines of the Lung

Front Cover
CRC Press, Sep 25, 1992 - Medical - 664 pages
Focusing on all the major cytokine families, this reference book provides coverage of cytokine regulatory processes in the lung and other tissues and comprehensive descriptions of cytokine functions specific to the lung.;Discussing the diverse cytokine-binding proteins and the role of cytokines in tissue injury and repair processes and extracellular matrix regulations, the book supplies information on amino acid structure and gene regulatory sequences, examines the receptor biology of individual cytokines, illustrates cytokine interactions with their cognate receptors and surveys the phenotypic effects of individual cytokines on target cells. With over 2700 literature citations and figures, this book is a resource for pulmonologists, physiologists, immunologists, cell and molecular biologists, environmental toxicologists, oncologists, and graduate-level and medical school students in these disciplines.
 

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Contents

PlateletDerived Growth Factor
3
Antiproliferative Effects of TGF8 113
35
Fibroblast Growth Factors
41
Structural Properties
42
FGF Receptors
48
Interaction with Extracellular Matrix
52
Biological Properties
54
The Role of FGFs in Tumor Formation
58
Conclusion
168
References
169
PROINFLAMMATORY CYTOKINES
183
Interleukin1
185
Historical Perspective
186
Synthesis
188
IL1 Receptor
191
Signal Transduction
194

FGFs in Lung Biology
60
References
62
InsulinLike Growth Factors
77
IGF Genes and Transcripts
78
IGF Receptors
80
IGFBinding Proteins
82
Actions of IGFs
84
Role of IGFs in Fetal Growth
86
IGFs and Lung
87
Summary
92
Transforming Growth Factor8
101
The TGF8 Family of Proteins
103
Biosynthesis of TGF8
104
Control of TGF8 Gene Expression
106
Receptors for TGF8
108
Signaling Pathways for TGF8
109
TGF8 as a Mitogen
111
TGF8 and Extracellular Matrix
115
Interactions Between TGF8 and Other Cytokines
117
TGF8 in MonocyteMacrophages Granulocytes and Mast Cells
119
Assays for TGF8
120
TGF8 in Lung
122
TGF8 in Remodeling and Fibrosis
124
Future Directions
127
Transforming Growth Factora and Epidermal Growth Factor
139
The Growth Factor Precursor Molecules
140
The Growth Factor Genes
146
StructureFunction Relationships of the Growth Factors
147
The EGF Receptor
149
Biological Responses to TGFa and EGF
155
The Role of TGFa and EGF in Lung Development
157
The Role of TGFa and EGF in Pulmonary Neoplasia
160
The Role of TGFa and EGF in Lung Repair
167
IL1 Inhibitors
196
IL1 Effects
198
Interleukin6 and the Lung
229
Interleukin8
281
Tumor Necrosis Factor
307
EnzymeReleasing Peptide
333
Macrophage Inflammatory Protein1
369
Myeloid Growth Factors in the Lung
383
334
400
FibroblastPneumonocyte Factor
403
Conclusion
410
Pulmonary Sources of TNF Production
411
356
414
Cytokines and Alveolar Type II Cells
417
Surfactant Secretion
423
358
448
CytokineBinding Proteins
459
The InsulinLike Growth FactorBinding Proteins
474
Cytokine Effects on Extracellular Matrix
491
Extracellular Matrix in the Abnormal Lung
501
Indirect Effects of Cytokines on Extracellular Matrix
516
Perspectives and Future Directions
523
369
535
370
548
501
549
229
555
516
560
247
579
Subject Index
627
383
628
281
629
307
639
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