Cytomegaloviruses: Molecular Biology and Immunology

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Matthias J. Reddehase, Niels Lemmermann
Horizon Scientific Press, 2006 - Medical - 619 pages
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Cytomegaloviruses are members of the herpesvirus group and can infect humans and other primates. Between 50-80% of adults in developed countries and up to 100% in developing countries are infected with human cytomegalovirus. Infection causes problems in immunocompromised hosts including AIDS victims or patients undergoing organ and stem cell transplantation and congenital infection can cause birth defects in the child. Development of an effective vaccine has high priority. In this book, leading international experts provide comprehensive and authoritative reviews on every aspect of current research. By integrating viral genomics, proteomics, immunology, and molecular biology with the emerging knowledge of the genomics of the host organism, penetrating new insights into the virus-host interaction are provided. The focus of the book is on the molecular and genomic aspects and the authors provide an insight into the current understanding of the subject and the future direction of research. Topics covered include disease mechanisms, genomics, proteomics, BAC mutagenesis, virus entry and activation of innate immunity, regulation of viral gene expression, regulation of viral mRNA export, animal models of infection, novel therapeutics, vaccine development, antivirals, and much more.
 

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Contents

IV
1
V
29
VI
49
VII
63
VIII
90
IX
111
X
131
XI
151
XX
340
XXI
367
XXII
382
XXIII
419
XXIV
445
XXV
465
XXVI
482
XXVII
501

XII
167
XIII
184
XIV
205
XV
231
XVI
245
XVII
265
XVIII
284
XIX
321
XXVIII
525
XXIX
551
XXX
573
XXXI
591
XXXII
606
XXXIII
611
XXXIV
617
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