Cytoskeleton and Human Disease
Springer Science & Business Media, Apr 23, 2012 - Science - 456 pages
The cytoskeleton is comprised of a variety of specialized proteins, and is a dynamic structure that is involved in the majority of key cellular events. There is increasing interest in the role of the cytoskeleton in human disease. This volume brings together human disease states where cytoskeletal disruptions are driving disease. Our emerging understanding of the molecular and cellular events that drive cytoskeletal mediated diseases including cancer, heart disease, myopathies and skin disorders, are also helping shape targeted therapeutic approaches to treating these diseases.
What people are saying - Write a review
We haven't found any reviews in the usual places.
Other editions - View all
abnormalities Acad Sci U S A actin actin cytoskeleton actin filaments actin isoforms activity Alzheimer’s disease apoptosis associated axonal binding Biochem Biol Chem brain cancer cells Cancer Res cardiac cardiomyopathy Cell Biol cell cycle cell lines Cell Motil cellular Clin clinical cofilin complex cortical Curr cytoskeleton defects desmin differentiation dimer disorders disruption domain drug epothilone expression F-actin filamin formation function gene human inhibition interactions intermediate filament involved isoforms isotypes kinase kinesin lamin laminopathies LIMK1 mechanism membrane mice microtubule microtubule dynamics migration mitotic Mol Biol Cell Mol Cell molecular motor mouse model mRNA mutations myopathy myosin N-terminal Natl Acad Sci nemaline myopathy neurofilament neuronal Neurosci nuclear overexpression paclitaxel pathway patients phenotype phosphorylation polymerization posttranslational modifications Proc Natl Acad protein receptor regulation role signaling skeletal muscle specific spectrin stathmin stereocilia STMN structure studies subunit syndrome targeting tau protein tauopathy tissues tubulin tumor tyrosine vitro