DNA Methylation: Basic Mechanisms
Walter Doerfler, Petra Böhm
Springer Science & Business Media, Feb 25, 2006 - Medical - 324 pages
The structural and functional importance of the correct patterns of DNA methylation in all parts of a mammalian genome is, unfortunately, not well understood. The stability, inheritability, and developmental flexibility of these patterns all point to a major role that these patterns appear to play in determining structure and funtion of the genome. Up to the present time, studies on the repetitive sequences, which comprise more than 90 per cent of the DNA sequences in the human or other genomes, have been neglected.
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Facts Clues Mysteries
DNA Methylation in Plants
De Novo Methylation LongTerm Promoter Silencing Methylation Patterns
Establishment and Maintenance of DNA Methylation Patterns in Mammals
Molecular Enzymology of Mammalian DNA Methyltransferases 203
Mutagenesis at Methylated CpG Sequences 259
Cytosine Methylation and DNA Repair
Other editions - View all
5-methylcytosine Acad Sci USA activity Ad12 DNA adenine adenovirus adenovirus type Arabidopsis Bestor TH binding Biochem Biol Chem cancer cell lines cellular Chen chromatin chromosome cloned CpG islands CpG methylation CpG sites cytosine cytosine methylation deamination demethylation DNA methylation DNA methylation patterns DNA methyltransferase DNA replication DNA sequences Dnmt1 Dnmt2 Dnmt3a and Dnmt3b DNMTs Doerfler embryonic enzyme epigenetic eukaryotic foreign DNA function gene expression gene silencing genomic imprinting glycosylase hamster cells hemimethylated heterochromatin histone deacetylase histone H3 human hypermethylation imprinting inactivation integrated interaction Jaenisch Jeltsch Kirnos MBD4 mechanism MeCP2 methy methylated CpG methylated DNA mice mismatch modification Mol Biol Mol Cell mouse mutations N-terminal Nat Genet Natl Acad Sci novo methylation Nucleic Acids Res nucleotide ofthe Okano patterns of DNA phenotype Proc Natl Acad protein region regulation repair repression residues role specific target thymine tion tissues transcription transgene tumor unmethylated Vanyushin BF viral