DNA Methylation: Basic Mechanisms

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Walter Doerfler, Petra Böhm
Springer Science & Business Media, Feb 25, 2006 - Medical - 324 pages
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The structural and functional importance of the correct patterns of DNA methylation in all parts of a mammalian genome is, unfortunately, not well understood. The stability, inheritability, and developmental flexibility of these patterns all point to a major role that these patterns appear to play in determining structure and funtion of the genome. Up to the present time, studies on the repetitive sequences, which comprise more than 90 per cent of the DNA sequences in the human or other genomes, have been neglected.
 

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Contents

PartI Introduction
7
References
15
PartII PatternFormation
20
Facts Clues Mysteries
45
DNA Methylation in Plants
67
De Novo Methylation LongTerm Promoter Silencing Methylation Patterns
125
DNA methyltransferases
128
Establishment and Maintenance of DNA Methylation Patterns in Mammals
179
Molecular Enzymology of Mammalian DNA Methyltransferases 203
202
PartV EpigeneticPhenomena
227
Dual Inheritance
243
Mutagenesis at Methylated CpG Sequences 259
258
Cytosine Methylation and DNA Repair
283
Subject Index 317
316

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