Dancing with Interlocked Molecules: The Generation of Molecular Motion for Drug Delivery Applications and Harnessing Molecular Recognition to Create and Manipulate Exotic Structures

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Northwestern University, 2009 - 191 pages
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The final chapter (Chapter 5) describes an analogous system which no longer relies on external stimuli - such as light or magnetic fields - or non-selective internal stimuli, such as heat or pH. This novel, breakthrough system undergoes release, based on the presence of enzymes. Human diseases are known to over-express a number of enzymes. If we can promote release to occur in the local vicinity of these abundant biological markers, we could create an unparalleled targeted drug delivery system that would have the potential to eliminate any side-effects the drugs may normally elicit.

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