Definition of Pain and Distress and Reporting Requirements for Laboratory Animals: Proceedings of the Workshop Held June 22, 2000

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National Academies Press, Jan 26, 2001 - Science - 132 pages
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In this first in a proposed series of workshops on regulatory issues in animal care and use, the Institute for Laboratory Animal Research (ILAR) has addressed the existing and proposed requirements for reporting pain and distress in laboratory animals. The Animal Welfare Act, administered by the Animal and Plant Health Inspection Service of the United States Department of Agriculture (USDA), mandates that pain and distress in laboratory animals be minimized. USDA is considering two policy changes with regard to this specific mandate. Firstly, since there has been no functional definition of "distress," USDA has prepared such a definition and requested feedback from the scientific community on its usefulness for regulatory and reporting requirements.

The second issue concerns the pain and distress categorization scheme for reporting to USDA. Various groups and individuals have questioned the efficacy of the current categories, and specific changes have been proposed by the Humane Society of the United States. USDA is considering these and other potential changes to the existing scheme. Thus, given these potential changes to animal welfare policy, the aim of the ILAR/NIH joint workshop was to provide feedback to the USDA. The speakers were asked to address these two issues as well as to comment upon whether the information contained in the 1992 ILAR report Recognition and Alleviation of Pain and Distress in Laboratory Animals is still useful to investigators in assisting them to comply with regulations. The speakers provided perspectives based on their individual expertise in the areas of science of pain and distress, animal welfare policy, protocol review, and/or as representatives of relevant organizations or institutions. The following proceedings are an edited transcript of their presentations.


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Seriously, why is this author not concerned with acute pain in animals? All animal abuse is a concern to anyone with a conscience. Also, it is not assumed by anyone with half a brain that cats, dogs, rats, mice etc. feel pain in response to the same things that we do, it is an absolute fact that things that will hurt us will do the same thing for any one of these animals. 


USDA Perspective
PHS Policy Perspective
A Veterinary Behaviorists Perspective
Scientific Issues of Pain and Distress
The Humane Society of the United States Pain and Distress Initiative
Pain and Distress Caused by Experimental Procedures Is It Time for a Reality Check?
A View from the Trenches
Personal Experiences with Clinical Pain Management Study Design Mitigation of Scientific Confounders and Longterm Gains
Use of Laboratory Animals in the Postgenome Era
The History and Histrionics of Pain and Distress in Laboratory Animals
Panel Discussion with All Speakers
Appendix A APHISUSDA Policy 11 and Policy 12
Appendix 2 Proposed Rulemaking
Appendix C Glossary of Abbreviations
Appendix D Meeting Participants

AALAS Position Paper on the Recognition and Alleviation of Pain and Distress in Laboratory Animals
On Regulating Pain and Distress
An Industrial Perspective
Corners Still Unswept
Appendix E Meeting Agenda
Appendix F Biographical Sketches of Committee Members

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