Dermatological and Transdermal Formulations

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Kenneth A. Walters
CRC Press, Feb 20, 2002 - Medical - 592 pages
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Containing 350 illustrations, tables, and equations and covering AAPS/FDA guidelines for the experimentation and analysis of in vivo and in vitro percutaneous absorption, this reference provides comprehensive coverage of the development, preparation, and application of topical and transdermal therapeutic systems. Recognized international experts discuss the bioequivalence of dermatological and transdermal dosage forms. They explore the biochemistry and treatment of skin diseases, the structure and function of the skin, adverse dermal responses to drug formulations, mechanisms of drug transport through barrier membranes, and methods for measuring and modulating percutaneous permeation.
 

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Contents

Chapter 1 The Structure and Function of Skin
1
Chapter 2 Common Skin Disorders and Their Topical Treatment
41
Chapter 3 Basic Mathematical Principles in Skin Permeantion
61
Chapter 4 Skin Transport
89
Chapter 5 Methods for Studying Percutaneous Absorption
197
Chapter 6 Formulation Strategies for Modulating Skin Permeation
271
Chapter 7 Dermatological Formulation and Transdermal Systems
319
Chapter 8 Bioavailability and Bioequivalence of Dermatological Formulations
401
A Case for Multivariate Optimization and Product Homogeneity
499
Chapter 10 Safety Considerations for Dermal and Transdermal Formulations
511
Chapter 11 Trandermal Delivery and Cutaneous Reactions
529
Index
549
Back cover
575
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