DERMATOTOXICOLOGY 4ED

Front Cover
Francis N. Marzulli, Francis Nicholas Marzulli, Howard I. Maibach
CRC Press, Jun 1, 1991 - Medical - 1063 pages
This volume offers fundamental information on the mechanisms of the action of toxicants on the skin, the varied responses of skin to specific toxicants and approaches to evaluating dermal toxicity. Testing methods are examined and there is a review of dermatologic drugs and various chemicals.
 

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Contents

Pharmacologic and Toxicologic Effects of Topically Applied
1
Skin Permeability Theory in Relation to Measurements
3
Paul H Dugard
9
Other Factors That Affect the Sweat Gland
10
Lipid Metabolism
16
Mechanism of Action of Metal Salt Antiperspirants
18
Metabolism of Proteins
29
Efficacy
39
Elicitation of Hypersensitivity
299
Predictive Tests
305
Introduction
307
Guinea Pig Maximization Test GPMT 3 13
315
10
320
Evaluation of Some Common Contact Sensitizers
326
The Contact Urticaria Syndrome Geo von Krogh
341
Identification of Specific Antibodies
356

References
46
Discussion
48
Sebaceous Glands F J Ebling
55
Effects of Hormones on Sebaceous Glands
62
Cutaneous Biotransformations and Some Pharmacological
71
Effect of Thyroid Hormones
73
Miscellaneous Cutaneous Metabolic Reactions
82
References
83
Cutaneous Metabolism Edward L Rongone
93
Absorption
100
Sterols and Steroids
116
In Vitro Percutaneous Absorption Robert L Bronaugh
117
Parameters that Affect in Vivo Percutaneous Absorption
138
Introduction
139
Skin Irritation Testing in Animals Arthur H McCreesh
153
Animal Tests as Predictors of Human Responses
157
Discussion and Conclusions
167
Intrinsic Factors
180
Testing of Ophthalmic Therapeutic Formulations
181
Skin Irritation Testing In Animals
193
ImmuneComplexMediated Reactions
195
Repetitive Application
203
Discussion and Conclusions
208
Sources of Exposure for Humans
214
Cutaneous Metabolism
220
The Immune System
226
Specific Immunological UnresponsivenessTolerance
259
DesensitizationInduction of Specific Immunological Unresponsiveness
270
Factors Affecting Allergic Contact Sensitization Bertil
289
Bertil Magnusson and Albert M Kligman
291
Animals Nicole Hunziker 37
373
71
374
Wayne Wamer and Albert Giles
377
Photocontact Allergy in Humans
441
21
452
Intolerance to Food Additives Lennart Juhlin
455
Photopatch Testing
463
Epstein
465
Step
481
20
497
15
516
Early Time Course of Percutaneous Absorption
530
Role of Hair Follicles and Sweat Ducts in Percutaneous
536
Percutaneous Absorption of Gases and Vapors
543
Usefulness of Guinea Pig Tests for Detection of Contact
551
Summary and Conclusion
558
29
560
and Allen G Collins
607
John A Shadduck and Henry F Edelhauser
641
OECD Guidelines for Testing of Chemicals
713
Lymphokines 217
1046
755
1048
206
1049
447
1051
277
1052
597
1054
497
1059
625
1062
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