The Design of Studies for Medical Research
The 1.3 million–copy New York Times bestseller–entirely revised and filled with riveting, recently declassified information First published in 1988, this spellbinding biography was the first to expose the secret life of Wallis Warfield Simpson, the woman who captured a king, Britain’s Edward VIII. From the duchess’s first marriage to a bisexual aviator to her feud with the Queen Mother, the first edition The Duchess of Windsor unearthed a trove of astonishing revelations–and spent 23 weeks in the top five of the New York Times bestseller list. Now, Charles Higham has updated this extraordinary biography with new information on the numerous extramarital liaisons of both the duke and duchess, the bisexuality of the duke, the blackmail plot in Paris that almost brought the Windsors to ruin, and the secret radio broadcasts the duke and duchess made from France to Germany. Charles Higham (Los Angeles, CA) is the author of many bestselling books, including Murdering Mr. Lincoln, American Swastika, and Trading with the Enemy as well as biographies of Katharine Hepburn, Orson Welles, and others.
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What is Evidence?
Measurement Forms and Questionnaires
Principles of Study Size Calculation
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allocation alternative analysis anastrozole anticipated assessment bias calculations cancer candidate variables choice chosen clinical trials cluster cohort study compared comparison complete conducted corresponding cross-sectional study defined described determine diagnostic difference disease dose drug effect effect size efficacy eligibility endpoint ensure equal numbers equation equivalence estimate example Figure gemcitabine gives glaucoma hepatocellular carcinoma identified implies important individual inoperable hepatocellular carcinoma intervention investigators involved Journal lung cancer Machin mean method nolatrexed Normal distribution null hypothesis number of patients number of subjects observed obtained options outcome p-value parameters particular Phase II trial placebo planning population possible potential preclinical prognostic factors proportion protocol question questionnaire random randomised trial ratio recruited regression coefficients repeated measures reporting response rate risk sample sample size sample-size selected sequence situation specified standard statistical summarised survey survival Table tamoxifen telithromycin therapy toxicity treatment two-group width