Development of Novel Vaccines: Skills, Knowledge and Translational Technologies

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Alexander von Gabain, Christoph Klade
Springer Science & Business Media, Apr 23, 2012 - Medical - 306 pages
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“Development of novel vaccines” gives an overview of the tasks in basic research leading to the final product – the vaccine and its applications, belonging to the most complex biologics in the pharmaceutical field. Distinct from most textbooks in the vaccine arena, the current issue focuses on the translational aspect, namely, how research results can be transformed into life-saving medical interventions. Each chapter of the book deals with one important paradigm for the development of novel vaccines, along the value chain towards the final vaccine, and furthermore, with the inevitable tools required for this process. Contributions are prepared by teams of scientists, all of whom are experts in the field, most of them anchored in biomedical organizations devoted to translational culture, thereby lighting the certain topics from different views. This volume is a must read for researchers engaged in vaccine development and who really want to see their research results to become a product.

 

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Contents

1 Skills Knowledge and Translational Technologies Leading to Novel Vaccines
1
2 Finding Protective Bacterial Antigens
27
3 Enhancing and Tailoring the Immunogenicity of Vaccines with Novel Adjuvants
45
4 Vaccine Delivery Beyond Needles
73
5 Employing Live Microbes for Vaccine Delivery
87
6 Synthesizing Vaccines with Microbes
125
7 Purification and Formulation Silent but Important Players in Vaccine Development
145
8 CuttingEdge Approaches Toward Novel and CrossProtective Influenza Vaccines
189
9 Cutting Edge Approaches Toward Novel and CrossProtective Influenza Vaccines
205
10 Examples of Novel Registered Prophylactic Vaccines HPV and JEV
233
11 The Bumpy Road Toward Vaccine Registration How to Overcome Regulatory Hurdles
287
Index
301
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