Development of Novel Vaccines: Skills, Knowledge and Translational Technologies

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Alexander von Gabain, Christoph Klade
Springer Science & Business Media, Apr 23, 2012 - Medical - 306 pages
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“Development of novel vaccines” gives an overview of the tasks in basic research leading to the final product – the vaccine and its applications, belonging to the most complex biologics in the pharmaceutical field. Distinct from most textbooks in the vaccine arena, the current issue focuses on the translational aspect, namely, how research results can be transformed into life-saving medical interventions. Each chapter of the book deals with one important paradigm for the development of novel vaccines, along the value chain towards the final vaccine, and furthermore, with the inevitable tools required for this process. Contributions are prepared by teams of scientists, all of whom are experts in the field, most of them anchored in biomedical organizations devoted to translational culture, thereby lighting the certain topics from different views. This volume is a must read for researchers engaged in vaccine development and who really want to see their research results to become a product.


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1 Skills Knowledge and Translational Technologies Leading to Novel Vaccines
2 Finding Protective Bacterial Antigens
3 Enhancing and Tailoring the Immunogenicity of Vaccines with Novel Adjuvants
4 Vaccine Delivery Beyond Needles
5 Employing Live Microbes for Vaccine Delivery
6 Synthesizing Vaccines with Microbes
7 Purification and Formulation Silent but Important Players in Vaccine Development
8 CuttingEdge Approaches Toward Novel and CrossProtective Influenza Vaccines
9 Cutting Edge Approaches Toward Novel and CrossProtective Influenza Vaccines
10 Examples of Novel Registered Prophylactic Vaccines HPV and JEV
11 The Bumpy Road Toward Vaccine Registration How to Overcome Regulatory Hurdles

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