Developmental Biology

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Springer Science & Business Media, Dec 13, 1996 - Science - 328 pages
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No field of contemporary biomedical science has been more revolutionized by the techniques of molecular biology than developmental biology. This is an outstanding concise introduction to developmental biology that takes a contemporary approach to describing the complex process that transforms an egg into an adult organism. The book features exceptionally clear two-color illustrations, and is designed for use in both undergraduate and graduate level courses. The book is especially noteworthy for its treatment of development in model organisms, whose contributions to developmental biology were recognized in the 1995 Nobel Prize for physiology and medicine.
 

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Contents

Development Organisms Construct and Organize Themselves on the Basis of Inherited Information
1
Basic Stages Principles and Terms of Developmental Biology
9
Model Organisms in Developmental Biology
21
Comparative Review The Phylotypic Stage of Vertebrates Common versus Distinct Features and Aspects of Evolution
122
The Egg Cell and the Sperm Get a Dowry
137
The Start Fertilization and Activation of the Egg
146
Precisely Patterned Cleavage Divisions Are Driven by an Oscillator
156
Determination Cells Are Programmed and Committed to Their Fates
160
Development of the Nervous System Cell Migration Pathfinding and SelfOrganization
242
Heart and Blood Vessels Divergent Developmental Roads but One System in the End
257
Stem Cells Enable Continuous Growth and Renewal
263
Signal Molecules Control Development and Growth
274
Cancer Comes from Disturbed Growth and Differentiation Control
282
Metamorphosis A Second Embryogenesis Creates a Second Phenotype
289
Sex and the Single Gene
301
Regeneration and Renewal versus Loss and Death
310

Epigenetic Pattern Formation New Patterns Are Created During Development
165
Differentiation Is Based upon Differential Gene Expression that Is Programmed during Determination
202
Cell Differentiation Frequently Is Irreversible and Causes Cell Death Early Cell Death Can Be Programmed
222
Animal Morphogenesis Is Shaped Actively by Adhesion and Cell Migration
228
Cell Journeys Even Germ Cells and Cells of the Peripheral Nervous System Originate from Emigrant Precursors
235
Life and Death What Is the Major Mystery?
323
Bibliography
335
Index
373
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Page 357 - Hynes, RO (1992) Integrins: versatility, modulation, and signaling in cell adhesion, Cell, 69, 11-25.
Page 350 - McMahon, AP (1993). Sonic hedgehog, a member of a family of putative signaling molecules, is implicated in the regulation of CNS polarity.
Page 351 - Hemmati-Brivanlou, A., Kelly, OG, and Melton, DA (1994) Follistatin, an antagonist of activin, is expressed in the Spemann organizer and displays direct neuralizing activity. Cell 77, 283-295.
Page 371 - P., and Schutz, G. (1995). Steroid hormone receptors: Many actors in search of a plot. Cell 83, 851-857.
Page 362 - The product of the retinoblastoma susceptibility gene has properties of a cell cycle regulatory element. Cell, 58. 1085-1095, 1989.
Page 369 - Capecchi, MR (1980) High efficiency transformation by direct microinjection of DNA into cultured mammalian cells Cell 22, 479-488.
Page 351 - A. (1990). Activin can induce the formation of axial structures and is expressed in the hypoblast of the chick, Cell.
Page 355 - McGinnis, W. and Krumlauf, R. (1992). Homeobox genes and axial patterning. Cell, 68, 283-302.
Page 359 - Henderson CE. Camu W, Mettling C. Gouin A. Poulsen K. Karihaloo M, Rullamas J, Evans T. McMahon SB, Armanini MP, Berkemeier L, Phillips HS, Rosenthal A (1993) Neurotrophins promote motor neuron survival and are present in embryonic limb bud.

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