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2 The In Vitro Approach to Teratogenicity Testing
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abnormalities accumulation acid adrenal adult animals Beck behavioural teratology benzo Biochem Biol brain Cancer Carcinogenesis carcinogens cell Chatot chemicals chick compounds concentration concept culture cytochrome defects Dencker developmental enzyme differentiation DMBA dose Druckrey drug embryo Embryol Exp embryotoxic environmental enzyme etal experimental exposure fetal fetal tissues fetus fetuses function genetic gestation glucose glucose 6-phosphatase growth hepatic histiotrophic hormonal human increased induced inhibition injected investigations Ivankovic Juchau Kleihues Kochhar lens limb-buds liver malformations mammalian maternal mechanisms Merker metabolism metabolites methylmercury mice Morphol mother mouse neonatal Nervous system Neubert neural observed oestrogens organogenesis organs palate Pelkonen Perinatal period Pharmacokinetics Pharmacol placental postnatal potential pregnancy Prenatal protein psychoteratology reactive intermediates Saxen serum species stage studies substances techniques teratogenesis teratogenic teratogenic agents teratogenic effects Teratology test for teratogenicity thalidomide toxic Toxicol toxicology transplacental trypan blue tumours Ullberg uptake vitamin vitro vivo Vorhees Wilson xenobiotic yolk sac