Diagnosis and Management of Multiple Sclerosis
Clinically focused text discusses diagnosis, timing of treatment initiation, and treatment regimen options. Detailed tables on neurologic disorders are provided to assist in differential diagnoses. Guidance is provided on how to best manage initial occurrence of MS and relapses with case study examples. Treatment of symptoms and medical problems that often accompany MS is discussed, along with prognostic indications.
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Definition and Pathology
Epidemiology and Genetics
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Abbreviations abnormalities active acute agents antibodies assessment associated ataxia atrophy attacks atypical autoimmune Avonex axonal Betaseron biopsy brain stem CDMS cells cerebral chronic clinical and MRI clinical trials cognitive Copaxone corticosteroids criteria definite Demos Medical demyelination differential diagnosis disease course disease-modifying treatment disorders disseminated dose drug dysfunction early EDSS effects evaluation evidence Figure follow-up genes genetic head MRI immune indicated infection interferon lesions magnetic resonance imaging McDonald Committee ment mg/d mitoxantrone MRI findings MRI scans multiple scle multiple sclerosis myelin myelopathy neuroimaging Neurol neurological neuropathy normal Novantrone oligoclonal bands onset optic nerve optic neuritis paraclinical paresthesias paroxysmal attacks pathology patients periventricular placebo present prognosis progressive Rebif Reference regard relapse rate relapsing-remitting risk RRMS Screening significant spasticity specific spinal cord SPMS subtype suggestive suspected symptoms syndrome Table testing therapeutic therapy tients tion tiple sclerosis tive typical usually virus white matter workup worsening