Diet and Cancer: Molecular Mechanisms of Interactions
Maryce M. Jacobs
Springer US, May 31, 1995 - Medical - 222 pages
The fifth of the annual research conferences of the American Institute for Cancer Research was held September l-2, 1994, at the L'Enfant Plaza Hotel in Washington, DC. Appropriately, in view of current directions in research, the theme was "Diet and Cancer: Molecular Mechanisms of Interactions". This proceedings volume contains chapters from the platform presentations and abstracts from the poster session held on the end of the first day. The subtopics for the tl;rree sessions held were "Retinoids, Vitamins A and Din Cancer Prevention and Therapy," "Choline and Lipids: Signal Transduction, Gene Expression and Growth Regulation," and "Dietary Factors and Regulation of Oncogenes, Growth and Differentiation. " A general overview on vitamins A and D emphasized that A and D, in addition to their established roles in vision, reproduction, and bone mineral homeostasis, may play significant roles in regulating cell function. Vitamin A metabolites, trans-retinoic acid and 9-cis-retinoic acid, regulate growth and differentiation. Furthermore, vitamin A deprived animals were more susceptible to both spontaneous and carcinogen-induced tumors. Epidemiological studies showed a correlation between low A intake and higher incidences of certain types of human cancers. Conversely, all-trans retinoic acid is useful in treatment and control of certain types of cancer. Physiologically, Vitamin D is converted to the active form, l ,25-dihydroxyvitamin D (VD). VD regulates hormone production and secretion, myocardial contractility, vascu 3 3 3 lar tone, and growth inhibition and differentiation.
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A-c-Myc activity airway antibodies apoptosis assay B16 cells binding Biochem Biol biomarkers biopsies breast cancer breast cancer cells bronchial c-Myc c-Myc proteins C3Hf mice Cancer Res Cancer Research carcinogenesis carcinoma cell death cell growth cell proliferation cellular cervical cell cervical epithelial cells choline choline deficient colon culture cyclic AMP cytokeratin decrease dietary fat effects fatty acids Figure gene expression genome growth factor high fat diet HKc/GFI hormone HPV16-immortalized human papillomavirus IGFBP-3 incidence increased induced initiation keratinocytes levels lipid lipotrope deficiency liver lung cancer mammary glands mammary tumor markers medium membrane metaplasia methionine methylation MMTV molecular mRNA mutations Natl normal HKc Northern blot nuclear oncogenes p-carotene pathway prostate cancer protein kinase RARy mRNA rats fed retinoic acid receptor retinoids role serum signal specific studies synthesis TGF-B tissue transcription transfection treatment tumor cells tumorigenesis vitamin vitro vivo