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EXPOSURE TO INSECTICIDES F Matsumura and B V Madhukar Michigan State University USA 1 Introduction
General patterns of exposure
Direct exposure to pesticides
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acid activity agric aldrin Appl binding Biochem Biol Biophys biphenyls Bull carbamate carbaryl Casida catalyzed cent chemical chlordane chlorinated cholinesterase compounds concentration conjugation Conney Contam Coon cyclodiene cytochrome P-450 Dahm degradation detoxication diazinon dieldrin Dorough dose drug metabolism effect Environ epoxidase epoxidation ester excretion exposure Fc-Housefly Fd Chem formation fraction Gillett glucuronide glutathione heme hepatic hepatic microsomal heptachlor Hodgson housefly hydrocarbon hydrolysis hydroxylase hydroxylation increased increaud induced inhibition inhibitors insecticides insects interactions isomers Khan Krieger Kulkarni lindane liver mammals mechanism metabolites methyl parathion mice microsomal microsomal cytochrome P-450 microsomal enzymes mouse Murphy NADPH Nakatsugawa Neal organophosphate oxidase oxidation oxygen paraoxon Pestic pesticides Pharmac Pharmacol phenobarbital phosphate phosphorothioate Physiol Plapp pretreatment protein rabbit rat liver microsomes rat rat reaction reduced reductase residues soluble species spectral steroids strains studies substrate sulfoxide synthesis Terriere tissues toxicity Toxicol transferase vitro metabolism vivo xenobiotics y-HCH