Difficult Diagnoses in Breast Pathology
Breast cancer is the second leading cause of cancer death in women in the United States. For the pathologist, almost any breast lesion may produce diagnostic difficulty, especially due to frequently small samples (core biopsy specimens) and a variety of mimics and variants seen in specific types of lesions. Additionally, the difficulty of breast lesion diagnosis has risen dramatically in recent years due to the increased emphasis on stratifying patients for appropriate therapy on an individual basis; the wider range of both local and systemic therapeutic options, and the potential for earlier diagnosis through increased mammographic breast screening leading to a higher likelihood of a favorable outcome. Difficult Diagnoses in Breast Pathology provides a highly visual presentation of the major problems and questions that a pathologist is likely to encounter in the evaluation of common and uncommon breast diseases. Coverage includes needle core biopsy interpretation, diagnosis of precursor lesions, early stage disease, and recognition of neoplastic mimics and other misleading variants. In addition, this book emphasizes particularly difficult areas including the use of newer immunohistochemical markers. Throughout, the emphasis is on an easily accessible presentation with tables and lists of key points summarizing major findings and numerous high-quality images supporting the text. Difficult Diagnoses in Breast Pathology will be a valuable reference for every pathologist who deals with the diagnosis of breast diseases.
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acini angiosarcoma apocrine associated atypical ductal hyperplasia basal-like benign breast cancer breast carcinoma C-LCIS calcifications calponin carci carcinoma in situ cellular chromatin cinoma Clin Pathol clinical clinicopathologic columnar cell composed core biopsy cribriform cytokeratins cytoplasm DCIS differential diagnosis ductal carcinoma E-cadherin eosinophilic epithelial cells epithelium estrogen expression fibroadenoma fibromatosis FIGURE flat epithelial atypia foci gene HER2 high-grade histologic hyperplasia immunohistochemical Immunohistochemistry infiltrate intraductal papilloma invasive carcinoma invasive lobular carcinoma involved LCIS lesions lobular carcinoma lobular neoplasia lobules low-grade DCIS low-grade ductal luminal lymph node malignant mammary markers membrane metaplastic carcinoma microinvasion mitotic molecular morphologic mucinous carcinoma myoepithelial cell layer myoepithelial cells necrosis neoplastic cells noma nuclear atypia nuclear grade nuclei nucleoli Oncol P-LCIS papillary lesions Pathologic Features patients phyllodes tumor pleomorphic present prognosis proliferation radial scar receptor S-LCIS Sclerosing adenosis shows spindle cell stain stroma subtypes Surg Pathol surgical excision therapy tissue tubular tumor cells variant