Dimorphism in Human Pathogenic and Apathogenic Yeasts
Joachim F. Ernst, Axel Schmidt
Karger, Jan 1, 2000 - Medical - 246 pages
The importance of yeast pathogens causing life-threatening systemic and tenacious superficial infections in humans has been steadily increasing over the last few decades. Species of the genus Candida, as well as dimorphic fungi with a pathogenic yeast phase such as Histoplasma and Cryptococcus species cause systemic mycosis mainly in immunocompromised patients and following long-term therapy with broad-spectrum antibiotics and/or antifungals. In recent years, our knowledge of the molecular biology of yeast pathogens has increased dramatically and is beginning to affect diagnostic and therapeutic strategies. A wealth of new information has appeared on the key virulence factors of yeast pathogens, including dimorphism, which is one of the striking features of most yeast pathogens. Written by international experts in the field, this book introduces yeast pathogens with a comprehensive guideline on yeast systematics and taxonomy. Furthermore, current therapies of yeast infections are discussed. A special focus is devoted to the most recent findings on dimorphism in yeast. Chapters on dimorphism in Candida albicans, other important yeast pathogens, as well as nonpathogenic yeasts stress similarities and differences in morphogenetic processes between yeast species. Both clinicians and basic research scientists will benefit greatly from the well-edited and up-to-date information collected in this volume.
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Molecular Approaches for Analyzing Diversity and Phylogeny among
Yeast Infections in Humans with Special Emphasis on Malassezia furfur
Yeast Infections in Veterinary Medicine
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actin activity agar amphotericin analysis antifungal ascomycetous Bacteriol basidia basidiomycetous budding yeast Candida albicans Candida species candidiasis candidosis Cell Biol cell wall chitin chromosomes Clin clinical cloned cryptococcosis Cryptococcus neoformans cultures cytoskeleton diploid disease EFG1 Efglp enzymes expression extracellular filamentous growth Fink GR fluconazole fungal fungemia fungi fungus furfur gene encoding genetic genome germ tube haploid heat shock Histoplasma capsulatum homolog host Human Pathogenic hyphal hyphal formation hyphal growth HYR1 identified immunocompromised induced Infect Immun invasive isolated itraconazole Kurtzman CP Malassezia mannoproteins Maresca membrane meningitis Microbiol mitochondrial molecular morphogenesis morphology mtDNA mutants mycelial Mycol organism pachydermatis patients phase phenotype phylogenetic protein proteinases pseudohyphal cells pseudohyphal development pseudohyphal growth regulation response Rhodotorula ribosomal role rRNA Saccharomyces cerevisiae SAP2 secreted sequence serum signalling pathways skin strains studies subunit switch teleomorphic temperature therapy tissue transcription Trichosporon vitro Yarrowia lipolytica yeast yeast cells yeast form yeast-hypha transition