Discovery of Novel Opioid MedicationsU.S. Department of Health and Human Services, Public Health Service, National Institutes of Health, National Institute on Drug Abuse, 1995 - Drug addiction - 309 pages |
Common terms and phrases
abstinence syndrome action activity acute addiction administration agonist alfentanil analgesic analgesic effect antinociceptive assay attenuated behaviors Bhargava Brain Res buprenorphine CCI rats cells chronic clinical compound concentrations DADLE development of tolerance dopamine dorsal horn dose DRG neurons Drug Abuse dynorphin effect of morphine enkephalin enzyme excitatory opioid receptors figure formalin formalin test Fournié-Zaluski ganglioside GM1 ganglioside haloperidol heroin hyperalgesia increase induced inhibition injection kelatorphan Kornetsky L-NARG mechanisms metabolism methoclocinnamox mg/kg mice mixed inhibitors morphine tolerance morphine withdrawal morphine-dependent naloxone naloxone-precipitated naltrexone NCADI neuropathic pain Neurosci NMDA antagonists NMDA receptor antagonists NOArg nociceptive NTIS PB opiate opioid agonists opioid peptides opioid receptors opioid tolerance opioid withdrawal peptidase peripheral Ph.D Pharmacol Exp Ther pharmacological physical dependence potential pretreatment response Roques Shen and Crain spinal cord stimulation studies thiorphan tolerance and dependence treatment vivo wet dog shakes withdrawal syndrome Yaksh