Draft toxicological profile for methylenedianline
U.S. Dept. of Health and Human Services, Public Health Service, Agency for Toxic Substances and Disease Registry, 1996 - Medical - 149 pages
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103 weeks Lamb 4,4'-methylenedianiline in humans 4,4'-methylenedianiline toxicity absorption acute adducts administered amines amounts of 4,4'-methylenedianiline analytical methods assess ATSDR biological biomarkers body weight cancer carcinogenicity chemical Cocker compound containing 4,4'-methylenedianiline contaminated with 4,4'-methylenedianiline dermal dermal exposure dermal route detection limit determination dianiline drinking water DuPont effects in humans effects of 4,4'-methylenedianiline El-Hawari environmental ethanol excretion exposed exposure to 4,4'-methylenedianiline Fukushima gamma-butyrolactone gastrointestinal gastrointestinal tract gavage genotoxic guinea pigs hazardous waste hazardous waste sites HEALTH EFFECTS hemoglobin hepatic HSDB HUMAN EXPOSURE IARC information was located ingestion inhalation exposure Kopelman levels of 4,4'-methylenedianiline liver LOAEL located regarding LSE tables metabolic metabolites methylenedianiline mg 4,4'-methylene mg 4,4'-methylenedianiline/kg mg 4,4'-methylenedianiline/kg/day mg/kg mg/kg/day for 103 mice NIOSH NOAEL Occupational oral exposure organs Pludro polyurethane potassium carbonate potential rats treated reported route of exposure samples skin soil studies were located thyroid tissues urinary bladder urine water for 13 workers workplace