Drug-Eluting Stents: Advanced Applications for the Management of Coronary Disease

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Christopher J. White
CRC Press, Jun 30, 2005 - Medical - 156 pages
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The cure for restenosis has been the Holy Grail of interventional cardiology since the advent of coronary angioplasty in the late 1970s. The development of stents improved the durability of angioplasty, but in-stent restenosis was a major problem for patients and the physicians. To deliver drugs locally on stents that prevent restenosis is a revolutionary advance. Percutaneous revascularization technology has leaped forward, dramatically altering clinical practices, with what may be the single most important advance in the history of cardiology. There are new delivery platforms and new drugs currently being tested. Despite the continuing advancement, there was a need to collate in a single text, information on drug eluting stents for coronary disease. Chris White and colleagues have put together a logically organized text that progresses from theory to practice, and addresses pharmacologic, technical and strategic issues as they relate to the placement of coronary drug-eluting stents.

 

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Contents

1 INTRODUCTION AND OVERVIEW
3
2 MECHANISMS OF RESTENOSIS FOLLOWING PERCUTANEOUS CORONARY INTERVENTIONS
7
ANTIPROLIFERATIVE DRUGS AND POLYMER COTINGS
19
TREATMENT OF RESTENOSIS
31
4 TRIALS OF ORAL DRUG THERAPY TO REDUCE RESTENOSIS
33
5 NONSTENT DEVICES TO REDUCE RESTENOSIS
41
6 CLINICAL TRAILS OF BARE MENTAL STENTS TO REDUCE RESTENOSIS
57
CLINICAL EXPERIENCE WITH DRUGELUTING STENTS
67
9 COMPLICATIONS RELATED TO DRUGELUTING STENTS
95
OPTIMAL PATIENT MANAGEMENT AND SELECTION FOR DRUGELUTING STENTS
105
10 PATIENT SELECTION CRITERIA FOR DUGSTENTS
107
11 OPTIMAL ANTIPLATELECT AND ANTIOCOAGERIAL THERAPY FOR DRUG ELUTING STENTS
115
12 OPTIMAL DEVELOPMENT STRATEGIES FOR DRUGELUTING STETS
125
COSTBENEFIT ANALYSIS AND FUTURE STRATEGIES FOR DRUGELUTING STENTS
135
13 COST ANALYSIS FOR CORONARY DRUGELUTING STENTS
137
14 THE FUTURE OF DRUGELUTING STENTS
145

BARE METAL STENTS VERSUS DRUGELUTING STENTS
69
8 BROADER INDIVIDUATION OFFLABEL USE FOR CORONARY DRUGELUTING STENTS
81

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