Drug Resistance As a Biochemical Target in Cancer Chemotherapy
Academic Press, Nov 12, 1991 - Medical - 368 pages
Drug Resistance as a Biochemical Target in Cancer Chemotherapy covers the proceedings of the 13th Bristol-Myers Squibb Symposium on Cancer Research, entitled ""Drug Resistance as a Biochemical Target in Cancer Chemotherapy"", hosted by the Japanese Foundation for Cancer Research in Tokyo. This book is divided into four parts encompassing 18 chapters that summarize the results of both preclinical and clinical research on circumvention of drug resistance.
The first two parts discuss the genetic aspects of multidrug resistance and the proteins involved in drug resistance. These parts also examine the structure, function, and expression of P-glycoproteins, with an emphasis on the role of these proteins as targets for cancer chemotherapy. The third part describes the methods for detection of P-glycoprotein and its antagonists to counter clinical drug resistance. This topic is followed by a discussion on the interactions among steroid hormones, steroid hormone receptors, antiandrogens, biological-response modifiers, and cytotoxic drugs in human breast cancer. The concluding part explores the clinical applications of chemosensitizers in cancer therapy. This part also considers the alternative clinical approaches against drug failure, including non-crosss-resistant therapies, autologous bone marrow transplantation, dose-intensive therapy, and high-dose chemotherapy.
Biomedical scientists and researchers and clinicians will find this book invaluable.
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PROTEINS INVOLVED IN DRUG RESISTANCE AS TARGETS FOR CANCER CHEMOTHERAPY
BASIC APPROACHES AGAINST CLINICAL DRUG RESISTANCE
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ABVD Acad Adriamycin agents ampliﬁcation AuBMT autologous bone marrow binding Biochem Biol Bonadonna breast cancer breast cancer cells camptothecin CANCER CHEMOTHERAPY Cancer Res cDNA cell lines cellular Chem chemotherapy Chinese hamster cleavable complex Clin clinical clones complete remission cross-resistance cyclophosphamide cytotoxic drugs DNA topoisomerase dose doxorubicin drug resistance effects encoded enzyme estrogen expression ﬁrst Fojo function gene product Gottesman GPEI Gros Hamada high-dose Hodgkin’s disease homology hormonal Horwitz human breast cancer human MDR1 inhibit interactions isoform leukemia levels Ling lymphoma mammalian MDR cell MDR1 MDR1 gene MDR3 mechanism membrane methotrexate mice Molecular monoclonal antibodies MOPP MOPP/ABVD mouse mRNA multidrug resistance mutants myeloma Natl Oncol overexpression P-glycopro P-glycoprotein P-glycoprotein genes P-gp Pastan patients Proc protein receptor regimens response Roninson sequence signiﬁcant sistance speciﬁc studies tamoxifen TARGET tein therapy tion tissues topoisomerase II toxicity treatment Tsuruo tumor cells verapamil vinblastine vincristine vitro Wang yeast